2-苯甲酰基-3,3-二(甲基硫代)丙烯腈合成路线 （共 4 条）
反应条件
1: 3-Oxo-3-phenylpropanenitrile With sodium hydride in tetrahydrofuran
T=0°C; 0.75 h;
2: carbon disulfide in tetrahydrofuran
T=20°C; 2 h;
3: methyl iodide in tetrahydrofuran
T=0 - 20°C; 18 h;
参考文献
TRIAD THERAPEUCTICS, INC.
Patent: WO2005/9973 A1, 2005 ;
Location in patent: Page/Page column 87 ;
WO 2005/009973 A1
反应条件
in pyridine
T=180 - 190°C; 1 h;
参考文献
Singh, Gurdeep; Ila, Hiriyakkanavar; Junjappa, Hiriyakkanavar
Synthesis, 1985 , # 2 p. 165 - 169
反应条件
in dimethyl sulfoxide
2 h; Ambient temperature;
参考文献
Rudorf, W. D.; Augustin, M.
Phosphorus and Sulfur and the Related Elements, 1980 , vol. 9, p. 329 - 336
反应条件
1: 98 percent / NBS / CCl4 / 1.5 h / Ambient temperature
2: 78 percent / various solvent(s); pyridine / 1 h / 180 - 190 °C
View Scheme
参考文献
Singh, Gurdeep; Ila, Hiriyakkanavar; Junjappa, Hiriyakkanavar
Synthesis, 1985 , # 2 p. 165 - 169
