1-甲基-5-硝基-1H-吲哚合成路线 （共 20 条）
反应条件
1: 5-Nitro-1H-indole With sodium hydride in N,N-dimethyl-formamide T=20°C; 1 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C;
参考文献
The United States of America, as represented by the Secretary, Department of Health and Human Services; Science Applications International Corporation (SAIC); Albany Molecular Research, Inc.
Patent: WO2009/42907 A1, 2009 ;
Location in patent: Page/Page column 36 ;
WO 2009/042907 A1
反应条件
potassium carbonate in n-heptane; ethyl acetate; N,N-dimethyl-formamide
参考文献
Hoffmann-La Roche Inc.
Patent: US6326501 B1, 2001 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide 3 h; Green chemistry;
参考文献
Jiang, Xinglong; Tiwari, Ashish; Thompson, Maethonia; Chen, Zhihong; Cleary, Thomas P.; Lee, Thomas B. K.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 604 - 608
反应条件
sodium hydroxide in N,N-dimethyl-formamide T=25 - 30°C; Large scale reaction;
参考文献
Goverdhan, Gilla; Reddy, Anumula Raghupathi; Sampath, Aalla; Srinivas, Kurella; Himabindu, Vurimidi; Reddy, Ghanta Mahesh
Organic Process Research and Development, 2009 , vol. 13, # 1 p. 67 - 72
反应条件
1: 5-Nitro-1H-indole With sodium hydride in N,N-dimethyl-formamide T=17 - 25°C; 0.25 h; 2: methyl iodide in N,N-dimethyl-formamide T=17 - 25°C; 3 h;
参考文献
WO2006/40520 A1, ;
Page/Page column 124-125 ;
WO 2006/040520 A1
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C;
参考文献
Gurkan, A. Selen; Karabay, Arzu; Buyukbingol, Zeliha; Adejare, Adeboye; Buyukbingol, Erdem
Archiv der Pharmazie, 2005 , vol. 338, # 2-3 p. 67 - 73
反应条件
1: With copper(I) oxide in 1,4-dioxane T=95 - 100°C; Friedel Crafts alkylation; Large scale reaction; 2: With hydrogen in water; ethyl acetate T=25 - 30°C; P=3677.86 - 4413.43 Torr; Large scale reaction;
参考文献
Goverdhan, Gilla; Reddy, Anumula Raghupathi; Sampath, Aalla; Srinivas, Kurella; Himabindu, Vurimidi; Reddy, Ghanta Mahesh
Organic Process Research and Development, 2009 , vol. 13, # 1 p. 67 - 72
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone 1.) THF, Et2O, -10 deg C, 30 min, 2.) THF, Et2O, from -10 deg C to RT, 30 min; Yield given. Multistep reaction;
参考文献
Forbes, Ian T.; Ham, Peter; Booth, Deborah H.; Martin, Roger T.; Thompson, Mervyn; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2524 - 2530
反应条件
hydrogen; palladium on activated charcoal in ethanol T=40°C;
参考文献
Ferlin, Maria Grazia; Chiarelotto, Gianfranco; Dall'Acqua, Stefano; MacIocco, Elisabetta; Mascia, Maria Paola; Pisu, Maria Giuseppina; Biggio, Giovanni
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 10 p. 3531 - 3541
反应条件
potassium hydroxide in water Electrolysis;
参考文献
Canadian Journal of Chemistry, , vol. 81, # 10 p. 1108 - 1118
