1-甲基-5-硝基-1H-吲哚合成路线 （共 20 条）
反应条件
sulfuric acid in water Electrolysis;
参考文献
Canadian Journal of Chemistry, , vol. 81, # 10 p. 1108 - 1118
反应条件
sulfuric acid in water Electrolysis;
参考文献
Canadian Journal of Chemistry, , vol. 81, # 10 p. 1108 - 1118
反应条件
1: 1-methyl-5-nitro-1H-indole; 3-methoxy-4-bromomethyl-benzoic acid methyl ester With copper(I) oxide in 1,4-dioxane T=95 - 100°C; Friedel Crafts alkylation; Large scale reaction; 2: With hydrogen in ethyl acetate T=25 - 30°C; P=3677.86 - 4413.43 Torr; Large scale reaction; 3: 2-toluenesulfonamide; cyclopentyl Chloroformate Further stages;
参考文献
Goverdhan, Gilla; Reddy, Anumula Raghupathi; Sampath, Aalla; Srinivas, Kurella; Himabindu, Vurimidi; Reddy, Ghanta Mahesh
Organic Process Research and Development, 2009 , vol. 13, # 1 p. 67 - 72
反应条件
1: hydrogen; palladium 10 on activated carbon / 25 - 35 °C / 2250.23 - 2625.26 Torr / |Autoclave 2: 4-methyl-morpholine / 25 - 35 °C 3: silver(l) oxide / 1,4-dioxane / 20 - 100 °C View Scheme
参考文献
Goverdhan, Gilla; Reddy, Anumula Raghupathi; Himabindu, Vurimidi; Reddy, Ghanta Mahesh
Synthetic Communications, 2013 , vol. 43, # 4 p. 498 - 504
反应条件
caesium acetate; triphenylphosphine; palladium diacetate in N,N-dimethyl acetamide T=125°C; 24 h;
参考文献
Lane, Benjamin S.; Brown, Meghann A.; Sames, Dalibor
Journal of the American Chemical Society, 2005 , vol. 127, # 22 p. 8050 - 8057
反应条件
(1,3-di(2,4,6-(CH3)3-C6H2)-imidazol-2-ylidene)Pd(OAc)2; acetic acid T=60°C; 24 h;
参考文献
Deprez, Nicholas R.; Kalyani, Dipannita; Krause, Andrew; Sanford, Melanie S.
Journal of the American Chemical Society, 2006 , vol. 128, # 15 p. 4972 - 4973
反应条件
tetrabutyl ammonium fluoride; palladium diacetate; acetic acid; silver(l) oxide in tetrahydrofuran; ethanol T=20°C; Inert atmosphere; regioselective reaction;
参考文献
Liang, Zunjun; Yao, Bangben; Zhang, Yuhong
Organic Letters, 2010 , vol. 12, # 14 p. 3185 - 3187
反应条件
pyridinium chlorochromate in 1,2-dichloro-ethane T=80°C; 2.5 h;
参考文献
Kumar, Chebolu Naga Sesha Sai Pavan; Devi, Chebrolu Lavanya; Rao, Vaidya Jayathirtha; Palaniappan, Srinivasan
Synlett, 2008 , # 13 p. 2023 - 2027
反应条件
1: 1-methyl-5-nitro-1H-indole; 3-methoxy-4-bromomethyl-benzoic acid methyl ester With copper(I) oxide in 1,4-dioxane T=95 - 100°C; Friedel Crafts alkylation; Large scale reaction; 2: With hydrogen in ethyl acetate T=25 - 30°C; P=3677.86 - 4413.43 Torr; Large scale reaction; 3: 2-toluenesulfonamide; cyclopentyl Chloroformate Further stages;
参考文献
Goverdhan, Gilla; Reddy, Anumula Raghupathi; Sampath, Aalla; Srinivas, Kurella; Himabindu, Vurimidi; Reddy, Ghanta Mahesh
Organic Process Research and Development, 2009 , vol. 13, # 1 p. 67 - 72
反应条件
1: H2 / Raney Ni / ethanol / 2068.59 Torr
2: 552 mg / pyridine; DMAP
View Scheme
参考文献
Lane, Benjamin S.; Sames, Dalibor
Organic Letters, 2004 , vol. 6, # 17 p. 2897 - 2900
