1: With bis(cyclopentadienyl)titanium dichloride; iso-propylmagnesium bromide in tetrahydrofuran 24 h; Reflux; 2: With water T=0°C;

1.1: iso-propylmagnesium bromide; bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 24 h / |Reflux 1.2: 0 °C 2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 18 h / |Reflux 3.1: sodium methylate; methanol / 6 h / 20 °C View Scheme

1.1: iso-propylmagnesium bromide; bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 24 h / |Reflux 1.2: 0 °C 2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 18 h / |Reflux 3.1: sodium methylate; methanol / 6 h / 20 °C 4.1: Salmonella typhimurium O2-dependent tRNA modifying monooxgenase; dihydrogen peroxide / dimethyl sulfoxide / 1 h / 27 °C / pH 8 / |Enzymatic reaction View Scheme

1.1: iso-propylmagnesium bromide; bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 24 h / |Reflux 1.2: 0 °C 2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 18 h / |Reflux 3.1: sodium methylate; methanol / 6 h / 20 °C View Scheme