nitric acid

hydrogenchloride; sulfuric acid; nitric acid 2) ether; Multistep reaction;

hydrogenchloride; triethylamine in tetrahydrofuran

in acetonitrile Pd(OAc)2 and 4-nitrophenethylamine*HCl in MeCN were refluxed for 16 h, suspn. was filtered through MgSO4, solvent was removed, CH2Cl2 was added,PPh3 was added and stirred for 30 min; soln. was filtered through MgSO4 and concd., ppt. was filtered off, Et2O/n-hexane (1:1) was added to filtrate, ppt. was filtered, washed with n-hexane, and air-dried; elem. anal.;

1: 82 percent / Et3N / tetrahydrofuran / 17 h / 20 °C 2: H2 / Pd/C-ethylenediamine / tetrahydrofuran / 8 h / 20 °C / 760 Torr View Scheme

1: Na2CO3 / methanol / RT, 20h; reflux, 1 h 2: acetohydroxamate buffer, 1.0 M KCl / H2O / 25 - 40 °C / also with KOH or acetohydroxamic acid; also at 25 deg C in the presence of cosolvent (EtOH, MeCN), solvent effect; also in D2O and tritiated water View Scheme

ammonia in chloroform 0.333333 h;

1: Et3N / CH2Cl2 / 2 h / 0 °C 2: NaH / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 96 percent / sat. aq. NaHCO3 / tetrahydrofuran / 0 - 20 °C 2: H2 / 10percent Pd/C / methanol / 2 h / 2068.6 Torr View Scheme

potassium carbonate in N,N-dimethyl-formamide