N-乙氧羰基-4-哌啶酮合成路线 （共 74 条）
反应条件
1: 93 percent / TiCl3/Li / 1,2-dimethoxy-ethane / 1.) r.t., 4 h, 2.) reflux, 13 h 2: 86 percent / KOH / ethanol / 5.5 h / Heating View Scheme
参考文献
Cid; Seijas; Villaverde; Castedo
Tetrahedron, 1988 , vol. 44, # 19 p. 6197 - 6200
反应条件
1: 68.2 percent / dibutyl ether / 21 h / Ambient temperature 2: 71.4 percent / KOH / ethanol / 5 h / Heating View Scheme
参考文献
Protiva; Kopicova; Grimova
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 2 p. 636 - 643
反应条件
1: 1.) n-BuLi / 1.) n-hexane, THF, Et2O, -78 deg C, 1 h, 2.) n-hexane, THF, Et2O, RT, 16 h 2: 81 percent / TsCl, pyridine / CH2Cl2 / 58 h / Ambient temperature 3: 89 percent / 5N NaOH / ethanol / 20 h / Heating View Scheme
参考文献
Kubota, Hirokazu; Fujii, Masahiro; Ikeda, Ken; Takeuchi, Makoto; Shibanuma, Tadao; Isomura, Yasuo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 351 - 354
反应条件
1: isobutyl bromide, Mg / diethyl ether / 10 h / Heating 2: 83 percent / KOH / ethanol / 3 h / 130 °C / Heating View Scheme
参考文献
Sindelar; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 7 p. 1484 - 1497
反应条件
1: 1.) n-BuLi / 1.) n-hexane, THF, Et2O, -78 deg C, 1 h, 2.) n-hexane, THF, Et2O, RT, 16 h 2: 81 percent / TsCl, pyridine / CH2Cl2 / 58 h / Ambient temperature View Scheme
参考文献
Kubota, Hirokazu; Fujii, Masahiro; Ikeda, Ken; Takeuchi, Makoto; Shibanuma, Tadao; Isomura, Yasuo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 351 - 354
反应条件
1: With boron trifluoride diethyl etherate in diethyl ether T=-35°C; 1.5 h; 2: With hydrogenchloride; water 6 h; Heating / reflux;
参考文献
Commissariat a l'Energie Atomique
Patent: EP1997381 A1, 2008 ;
Location in patent: Page/Page column 16 ;
反应条件
1: 52.5 g / BF3*Et2O / diethyl ether / 1 h / -30 - -25 °C 2: 4 N HCl / 6 h / Heating View Scheme
参考文献
De Ruiter; Andurkar; Riley; Walters; Noggle Jr.
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 779 - 786
反应条件
1: 90 percent / diethyl ether 2: 87 percent / KOH / ethanol / 2 h / Heating View Scheme
参考文献
Protiva; Kopicova; Grimova
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 2 p. 636 - 643
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, Et2O, -78 deg C, 1 h, 2.) hexane, THF, Et2O, RT, 6 h 2: 73 percent / TsCl, pyridine / CH2Cl2 / 38 h / Ambient temperature 3: 5N aq. NaOH / ethanol / 24 h / Heating View Scheme
参考文献
Kubota, Hirokazu; Kakefuda, Akio; Nagaoka, Hitoshi; Yamamoto, Osamu; Ikeda, Ken; Takeuchi, Makoto; Shibanuma, Tadao; Isomura, Yasuo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 242 - 254
反应条件
boron trifluoride diethyl etherate in diethyl ether T=-30 - 20°C;
参考文献
Lyles-Eggleston; Altundas; Xia; Sikazwe; Fan; Yang; Li; Zhang; Zhu; Schmidt; Vanase-Frawley; Shrihkande; Villalobos; Borne; Ablordeppey
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 497 - 508
