N-乙氧羰基-4-哌啶酮合成路线 （共 74 条）
反应条件
1: 52.5 g / BF3*Et2O / diethyl ether / 1 h / -30 - -25 °C
2: 4 N HCl / 6 h / Heating
3: 30percent aq. K2CO3 / 4 h / -5 °C
4: ZnCl2 / toluene / 15 h / Heating
5: NaBH4 / methanol / 1 h / Heating
6: 85 percent / 48percent HBr / 3 h / Heating
View Scheme
参考文献
De Ruiter; Andurkar; Riley; Walters; Noggle Jr.
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 779 - 786
反应条件
1: 84 percent / 4-toluenesulfonic acid / toluene / 3 h / Heating
2: 62 percent / NaOH / ethanol; H2O / 20 h / Heating
View Scheme
参考文献
Moltzen; Perregaard; Meier
Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 2009 - 2017
参考文献
Protiva; Kopicova; Grimova
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 2 p. 636 - 643
反应条件
1.1: Mg / diethyl ether / 2 h / Heating
1.2: diethyl ether; tetrahydrofuran / 24 h / Heating
2.1: aq. KOH / ethanol / 12 h / Heating
View Scheme
参考文献
Lyles-Eggleston; Altundas; Xia; Sikazwe; Fan; Yang; Li; Zhang; Zhu; Schmidt; Vanase-Frawley; Shrihkande; Villalobos; Borne; Ablordeppey
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 497 - 508
反应条件
1: 1. Mg / 1. ether, 2. 1 h, room temperature, 90 min, reflux
2: 49 percent / KOH / ethanol / 5 h / Heating
View Scheme
参考文献
Vejdelek; Metys; Holubek; et al.
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 11 p. 2649 - 2660
反应条件
potassium hydroxide; iodine
T=0 - 20°C; 6.25 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2009/33581 A1, 2009 ;
Location in patent: Page/Page column 77-78 ;
反应条件
sodium iodide in methanol
T=30°C; Electrochemical reaction;
参考文献
Elinson, Michail N.; Dorofeev, Alexander S.; Feducovich, Sergey K.; Nasybullin, Ruslan F.; Litvin, Evgeny F.; Kopyshev, Mikhail V.; Nikishin, Gennady I.
Tetrahedron, 2006 , vol. 62, # 34 p. 8021 - 8028
反应条件
N-chloro-succinimide in acetone
T=0°C; 1 h;
参考文献
Wender, Paul A.; White, Alan W.
Tetrahedron, 1983 , vol. 39, # 22 p. 3767 - 3776
反应条件
sodium hydroxide; toluene-4-sulfonic acid in toluene
参考文献
Lundbeck; H.
Patent: US5665725 A1, 1997 ;
反应条件
toluene-4-sulfonic acid in toluene
3 h; Heating;
参考文献
Moltzen; Perregaard; Meier
Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 2009 - 2017
