7-溴-4-甲氧基-5-[(苯基甲氧基)甲基]-5H-吡咯并[3,2-d]嘧啶合成路线 （共 5 条）
反应条件
N-bromosuccinmide in dichloromethane T=0 - 20°C; 0.5 h; Inert atmosphereHeating;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; BANTIA, Shanta; WU, Minwan; KUMAR, V., Satish
Patent: WO2014/78778 A2, 2014 ;
Location in patent: Page/Page column 106-107 ;
反应条件
1: POCl3 2: NaH / tetrahydrofuran / 1 h / 20 °C 3: NaH / tetrahydrofuran / 1 h 4: 6.83 g / NBS / methanol; tetrahydrofuran View Scheme
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; BANTIA, Shanta; WU, Minwan; KUMAR, V., Satish
Patent: WO2014/78778 A2, 2014 ;
反应条件
1: NaH / tetrahydrofuran / 1 h / 20 °C 2: NaH / tetrahydrofuran / 1 h 3: 6.83 g / NBS / methanol; tetrahydrofuran View Scheme
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; BANTIA, Shanta; WU, Minwan; KUMAR, V., Satish
Patent: WO2014/78778 A2, 2014 ;
反应条件
1: ethanol / |Reflux 2: potassium hydroxide / 40 h / 20 - 60 °C 3: trichlorophosphate / 1 h / |Inert atmosphere; |Reflux 4: sodium hydride / tetrahydrofuran / 2 h / 4 °C / |Inert atmosphere 5: N-bromosuccinmide / dichloromethane / 0.5 h / 0 - 20 °C / |Inert atmosphere; |Heating View Scheme
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; BANTIA, Shanta; WU, Minwan; KUMAR, V., Satish
Patent: WO2014/78778 A2, 2014 ;
反应条件
1: potassium hydroxide / 40 h / 20 - 60 °C 2: trichlorophosphate / 1 h / |Inert atmosphere; |Reflux 3: sodium hydride / tetrahydrofuran / 2 h / 4 °C / |Inert atmosphere 4: N-bromosuccinmide / dichloromethane / 0.5 h / 0 - 20 °C / |Inert atmosphere; |Heating View Scheme
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; BANTIA, Shanta; WU, Minwan; KUMAR, V., Satish
Patent: WO2014/78778 A2, 2014 ;
