3,5-二碘-L-酪氨酸合成路线 （共 23 条）
反应条件
sodium hydrogencarbonate in methanol; water
参考文献
Chen, Ruijiao; Liu, Hao; Liu, Xiubing; Chen, Xiaochuan
Tetrahedron, 2013 , vol. 69, # 17 p. 3565 - 3570
反应条件
in dimethyl sulfoxide Ambient temperature;
参考文献
Hruby; Sawyer; Yang; Bregman; Hadley; Heward
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1432 - 1437
参考文献
Abderhalden; Guggenheim
Chemische Berichte, 1908 , vol. 41, p. 1239,1991
反应条件
1: methanol; L-4-hydroxy-3,5-diiodo-phenylalanine With thionyl chloride T=0°C; 2 h; Reflux; 2: With N-ethyl-N,N-diisopropylamine in dichloromethane T=0°C; 3: di-tert-butyl dicarbonate in dichloromethane T=20°C;
参考文献
ST. JUDE CHILDREN'S RESEARCH HOSPITAL; FUJII, Naoaki; ACTIS, Marcelo; PUNCHIHEWA, Chandanamali; CONNELLY, Michele; WU, Zhexiang
Patent: WO2013/6734 A1, 2013 ;
Location in patent: Paragraph 00586 ;
反应条件
in N,N-dimethyl-formamide T=24°C; 16 h; 0.2 M borate buffer, pH 8.0 (add. of 0.1 M NaOH);
参考文献
Salamonczyk, Grzegorz M.; Oza, Vibha B.; Sih, Charles J.
Tetrahedron Letters, 1997 , vol. 38, # 40 p. 6965 - 6968
反应条件
1: aq. NaOH solution 2: aq. NaOH solution View Scheme
参考文献
Myers
Journal of the American Chemical Society, 1932 , vol. 54, p. 3718,3724
参考文献
Barnes et al.
Journal of the Chemical Society, 1950 , p. 2824,2830
参考文献
Chen, Ruijiao; Liu, Hao; Liu, Xiubing; Chen, Xiaochuan
Tetrahedron, 2013 , vol. 69, # 17 p. 3565 - 3570
反应条件
1: 55 percent / 35 percent HCl / 1,2-dimethoxy-ethane / 18.5 h / 72 °C 2: 78 percent / NaOH / dioxane; H2O / 5 h / 20 °C 3: 54 percent / Et3N; H2 / 10 percent Pd/C / methanol / 4 h / 75006 Torr View Scheme
参考文献
Zhang, Yingjie; Feng, Jinhong; Jia, Yuping; Wang, Xuejian; Zhang, Lei; Liu, Chunxi; Fang, Hao; Xu, Wenfang
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2823 - 2838
参考文献
Fox
Journal of the American Chemical Society, 1946 , vol. 68, p. 194
