4-(4-氯苯基)-1,2,3,6-四氢-吡啶合成路线 （共 15 条）
反应条件
1: HCl; AcOH 2: HCl 3: NaOH View Scheme
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
反应条件
methanol; formaldehyd; ammonium chloride Erw. des Rktprod. mit konz. wss. Salzsaeure;
参考文献
Janssen et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1959 , vol. 1, p. 281,284
反应条件
in palladium on charcoal; ethyl acetate
参考文献
Shell Research Limited
Patent: US5489599 A1, 1996 ;
反应条件
1: potassium carbonate / acetone / 14 h / Heating
2: LiAlH4 / tetrahydrofuran / 10 h / Heating
View Scheme
参考文献
Gessner, Wieslaw; Brossi, Arnold; Shen, Rong-sen; Abell, Creed W.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 311 - 317
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide
T=45°C; 48 h;
参考文献
Nicolaou; Mathison, Casey J. N.; Montagnon, Tamsyn
Angewandte Chemie - International Edition, 2003 , vol. 42, # 34 p. 4077 - 4082
