N-叔丁氧羰基-3,4-二羟基-L-苯丙氨酸合成路线 （共 7 条）
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C;
参考文献
Persson, Jenny; Larsson, Rikard; Sterner, Olov; Johansson, Martin
Patent: US2012/157461 A1, 2012 ;
Location in patent: Page/Page column 12-14 ;
反应条件
acetic acid in ethyl acetate
反应条件
1.1: TBAF / tetrahydrofuran / 0.33 h 2.1: NaOH / dioxane; H2O / 0.17 h 2.2: 40.3 percent / dioxane; H2O / 20 h View Scheme
参考文献
Tetrahedron, , vol. 57, # 29 p. 6139 - 6146
反应条件
1.1: Et2NH / acetonitrile / 1 h 2.1: TBAF / tetrahydrofuran / 0.33 h 3.1: NaOH / dioxane; H2O / 0.17 h 3.2: 40.3 percent / dioxane; H2O / 20 h View Scheme
参考文献
Tetrahedron, , vol. 57, # 29 p. 6139 - 6146
反应条件
in N,N-dimethyl-formamide
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 16 p. 3081 - 3084
反应条件
1: potassium fluoride / N,N-dimethyl-formamide / 72 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 24 h / 20 °C 3: acetonitrile / 5.2 h / pH 7.2 / Photolysis; HEPES buffer View Scheme
参考文献
Fernandes, Maria Jose G.; Costa, Susana P.G.; Gonalves, M. Sameiro T.
Tetrahedron, 2011 , vol. 67, # 13 p. 2422 - 2426
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide
T=20°C; 7 h; Inert atmosphere;
参考文献
ONO PHARMACEUTICALS CO., LTD.; Kokubo, Masaya; Yano, Koji
Patent: US2013/245074 A1, 2013 ;
Location in patent: Paragraph 0356-0358 ;
