2-(4-(甲基磺酰基)苯基)乙酸甲酯合成路线 （共 6 条）
反应条件
Oxonereg; in methanol; water T=20°C; Cooling with ice;
参考文献
FAES FARMA, S.A.
Patent: EP2135864 A1, 2009 ;
Location in patent: Page/Page column 15-16 ;
反应条件
sulfuric acid in methanol
参考文献
Bizzarro, Fred Thomas; Corbett, Wendy Lea; Grippo, Joseph Francis; Haynes, Nancy-Ellen; Holland, George William; Kester, Robert Francis; Sarabu, Ramakanth
Patent: US2001/39344 A1, 2001 ;
US 20010039344 A1
Title/Abstract Full Text Show Details
Hoffman-La Roche Inc.
Patent: US6610846 B1, 2003 ;
US 6610846 B1
反应条件
sulfuric acid 16 h; Heating / reflux;
参考文献
NOVO NORDISK A/S
Patent: WO2006/58923 A1, 2006 ;
Location in patent: Page/Page column 47 ;
WO 2006/058923 A1
参考文献
Hutchby, Marc; Houlden, Chris E.; Haddow, Mairi F.; Tyler, Simon N. G.; Lloyd-Jones, Guy C.; Booker-Milburn, Kevin I.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 2 p. 548 - 551
反应条件
1: (4-methanesulfonyl-phenyl)-acetic acid methyl ester With N,N'-dimethyl-N,N'-propyleneurea; n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: (cyclopentyl)methyl iodide in tetrahydrofuran; hexane T=-78°C; 0.5 h;
参考文献
NOVO NORDISK A/S
Patent: WO2006/58923 A1, 2006 ;
Location in patent: Page/Page column 47-48 ;
WO 2006/058923 A1
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran
参考文献
Hoffman-La Roche Inc.
Patent: US6610846 B1, 2003 ;
US 6610846 B1
