N-苄基-L-组氨酸甲酯合成路线 （共 10 条）
反应条件
tetrafluoroboric acid; hydrogen; [Rh(COD)2]ClO4 in methanol; diethyl ether
T=19.84°C; P=750.075 Torr; 72 h; Title compound not separated from byproducts.;
参考文献
Cesarotti; Rimoldi; Zerla; Aldini
Tetrahedron Asymmetry, 2008 , vol. 19, # 3 p. 273 - 278
反应条件
TEA in chloroform
T=20°C; 48 h;
参考文献
Cesarotti; Rimoldi; Zerla; Aldini
Tetrahedron Asymmetry, 2008 , vol. 19, # 3 p. 273 - 278
反应条件
1: benzoic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane
0.25 h;
2: methyl (2S)-2-amino-3-(4-imidazolyl)propionate dihydrochloride With triethylamine in dichloromethane
T=20°C; 12 h; Inert atmosphere;
参考文献
Kumar, Atul; Gupta, Garima; Srivastava, Suman
Green Chemistry, 2011 , vol. 13, # 9 p. 2459 - 2463
反应条件
1: Et3N / CHCl3 / 0.5 h
2: NaOMe / methanol
View Scheme
参考文献
Campbell, John B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 1213 - 1218
反应条件
1: Et3N / CHCl3 / 0.5 h
2: NaOMe / methanol
View Scheme
参考文献
Campbell, John B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 1213 - 1218
反应条件
hydrogenchloride
<Nα-benzoyl-l-histidine >-methyl ester;
参考文献
Gerngross
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1919 , vol. 108, p. 58,62
反应条件
T=25°C; bei der Reaktion mit 1-Benzoyl-theobromin erhaelt man analog Hippursaeure und Theobromin;
参考文献
Bergmann; Zervas
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1928 , vol. 175, p. 150
Biochemische Zeitschrift, 1928 , vol. 203, p. 290
反应条件
T=25°C; bei der Reaktion mit 1-Benzoyl-theobromin erhaelt man analog Hippursaeure und Theobromin;
参考文献
Bergmann; Zervas
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1928 , vol. 175, p. 150
Biochemische Zeitschrift, 1928 , vol. 203, p. 290
反应条件
1-hippuryl-Nα-benzoyl-L-histidine methyl ester;
参考文献
Bergmann; Zervas
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1928 , vol. 175, p. 150
Biochemische Zeitschrift, 1928 , vol. 203, p. 290
反应条件
1: LiAlH4; THF; diethyl ether
2: aqueous HCl
View Scheme
参考文献
Bauer et al.
Biochemical Preparations, 1955 , vol. 4, p. 46,50
Full Text Show Details
Karrer; Saemann
Helvetica Chimica Acta, 1953 , vol. 36, p. 570
