(-)-1-[(4-氯苯基)苯甲基]哌嗪合成路线 （共 15 条）
反应条件
1: With hydrogen bromide; acetic acid T=70 - 75°C; 3 h; Industry scale; 2: With sodium hydroxide in water T=0 - 35°C; pH=~ 12 - ~ 14; Industry scale; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; RAMAYYA, Vaddadi Pattabhi
Patent: WO2009/62036 A2, 2009 ;
Location in patent: Page/Page column 21-22 ;
反应条件
1: With hydrogen bromide; acetic acid T=25 - 60°C; 5 h; 2: With water; sodium hydroxide in toluene
参考文献
US2009/281318 A1, ;
Page/Page column 3 ;
反应条件
1: With sulfuric acid in isopropyl alcohol T=20 - 90°C; 2: With sodium hydroxide in di-isopropyl ether; water; isopropyl alcohol
参考文献
US2010/145049 A1, ;
Page/Page column 8-9 ;
反应条件
potassium hydroxide in isopropyl alcohol T=80 - 85°C; 9 h;
参考文献
WO2012/101475 A1, ;
Page/Page column 14 ;
反应条件
1: With hydrogen bromide; acetic acid; 4-hydroxy-benzoic acid T=25°C; 17 h; 2: With sodium hydroxide in water Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; RAMAYYA, Vaddadi Pattabhi
Patent: WO2009/62036 A2, 2009 ;
Location in patent: Page/Page column 24-25 ;
反应条件
1: With N-ethyl-N,N-diisopropylamine 3 h; Heating / reflux; 2: With diethylamine T=60°C; 5 h; Heating / reflux; 3: With sodium hydroxide; water pH=10 - 11;
参考文献
WO2008/110586 A2, ;
Page/Page column 11; 20 ;
反应条件
sodium hydroxide; water T=20°C; 12.5 h; Product distribution / selectivity;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2009/78627 A2, 2009 ;
Location in patent: Page/Page column 8-9 ;
反应条件
sodium hydroxide; water in isopropyl alcohol T=20 - 100°C; Product distribution / selectivity;
参考文献
US2009/143582 A1, ;
Page/Page column 8 ;
反应条件
sodium hydroxide; water in isopropyl alcohol T=50°C; 3.5 h; Product distribution / selectivity;
参考文献
US2009/143582 A1, ;
Page/Page column 7 ;
反应条件
sodium hydroxide; water in isopropyl alcohol T=100°C; 5 h; Product distribution / selectivity;
参考文献
US2009/143582 A1, ;
Page/Page column 8-9 ;
