(-)-1-[(4-氯苯基)苯甲基]哌嗪合成路线 （共 15 条）
反应条件
sodium hydroxide; water in isopropyl alcohol 3 - 3.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
US2009/143582 A1, ;
Page/Page column 6 ;
反应条件
sodium hydroxide; water in isopropyl alcohol 1.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
US2009/143582 A1, ;
Page/Page column 7 ;
反应条件
sodium hydroxide; water in isopropyl alcohol 2.75 h; Heating / reflux; Product distribution / selectivity;
参考文献
US2009/143582 A1, ;
Page/Page column 7 ;
反应条件
1: N-ethyl-N,N-diisopropylamine / 128 - 130 °C 2: potassium hydroxide / isopropyl alcohol / 9 h / 80 - 85 °C View Scheme
反应条件
1.1: triethylamine / toluene / 7 h / 110 - 115 °C 1.2: 12 h / 25 - 30 °C 2.1: ammonia / toluene; water / 0.25 h / pH 8.5 - 9 2.2: 0 - 10 °C 2.3: pH 4.3 - 4.8 View Scheme
参考文献
JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; DUBEY, Shailendra, Kumar; MANGLA, Amit; MASAND, Mukesh; VIR, Dharam
Patent: WO2012/101475 A1, 2012 ;
