反应条件
1: Fmoc-Arg(Pbf)-Wang polystyrene resin With piperidine in N,N-dimethyl-formamide 0.0833333 h; Automated synthesizersolid phase reaction; 2: fmoc-L-Arg(Pbf)-OH With 1-methyl-pyrrolidin-2-one; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide 0.75 h; Automated synthesizersolid phase reaction; 3: 4-(hydroxymethyl)-benzoic acid; fmoc-L-Arg(Pbf)-OH Further stages;
参考文献
Harris, Paul W.R.; Brimble, Margaret A.
Synthesis, 2009 , # 20 p. 3460 - 3466
