N-(3-氨基-4-甲基苯基)-3-(三氟甲基)苯甲酰胺合成路线 （共 3 条）
反应条件
1: With tin(ll) chloride in DMF (N,N-dimethyl-formamide) T=25°C; 12 h; 2: With sodium hydroxide in DMF (N,N-dimethyl-formamide); water
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/3378 A1, 2006 ;
Location in patent: Page/Page column 68 ;
WO 2006/003378 A1
参考文献
AstraZeneca AB
Patent: US6579872 B1, 2003 ;
US 6579872 B1
反应条件
1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C 1.2: 60 °C 2.1: hydrogen / palladium on activated charcoal / methanol / 4 h View Scheme
参考文献
Folmer, Brigitte Johanna Bernita; Man, de Adrianus Petrus Antonius; Gernette, Elisabeth Sophia; Corte Real Goncalves Azevedo, Rita; Ibrahim, Hemen
Patent: US2013/79341 A1, 2013 ;
