3,5-双三氟甲基苯乙酮合成路线 （共 44 条）
反应条件
acetic anhydride; magnesium in tetrahydrofuran; water
参考文献
Brands, Karel M. Jos; Payack, Joseph F.; Pye, Philip J.
Patent: US2002/52493 A1, 2002 ;
反应条件
1: 3,5-bis-trifluoromethyl-benzoyl fluoride With N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; 0.5 h; 2: tetramethylstannane With PhCH2Pd(PPh3)2Cl T=65°C; 1 h;
参考文献
MITSUBISHI GAS CHEMICAL COMPANY, INC.
Patent: EP1500641 A1, 2005 ;
Location in patent: Page 10-11 ;
反应条件
sulfuric acid; dihydrogen peroxide; sodium tungstate; Aliquatreg; 336 in water; 1,2-dichloro-ethane T=50°C; 9 h;
参考文献
WO2004/94358 A1, ;
Page 4-5 ;
反应条件
1: 3,5-bis(trifluoromethyl)phenyl bromide With isopropylmagnesium chloride in tetrahydrofuran T=-10°C; 1 h; 2: acetic anhydride in tetrahydrofuran
参考文献
Leazer Jr., Johnnie L.; Cvetovich, Raymond; Tsay, Fuh-Rong; Dolling, Ulf; Vickery, Thomas; Bachert, Donald
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3695 - 3698
反应条件
1: 3,5-bis(trifluoromethyl)phenyl bromide With magnesium in tetrahydrofuran T=45°C; 2: acetyl chloride With copper(l) chloride in tetrahydrofuran T=30 - 40°C;
参考文献
US2004/19243 A1, ;
Page 3 ;
反应条件
hydrogenchloride; sodium acetate
参考文献
MITSUBISHI CHEMICAL CORPORATION
Patent: EP949243 A1, 1999 ;
反应条件
3 A molecular sieve; oxygen; (-)-sparteine; Pd((-)-sparteine)2Cl2 in tert-butyl alcohol T=65°C; 20 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 68, # 11 p. 4600 - 4603
反应条件
1.1: 94 percent / sulfuric acid; 1,3-dibromo-5,5-dimethylhydantoin / acetic acid / 4 h / 45 °C 2.1: i-PrMgCl / tetrahydrofuran / 1 h / -10 °C 2.2: 88 percent / tetrahydrofuran View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 9 p. 3695 - 3698
反应条件
in tetrahydrofuran; diethyl ether T=0 - 20°C; 5 h;
参考文献
WO2004/85404 A1, ;
Page/Page column 70 ;
WO 2004/085404 A1
反应条件
in tetrahydrofuran T=-15 - 10°C; 1 h;
参考文献
Merck and Co., Inc.
Patent: US6350915 B1, 2002 ;
Location in patent: Example 2 ;
