3,5-双三氟甲基苯乙酮合成路线 （共 44 条）
反应条件
(i) CuI, (ii) /BRN= 2593440/; Multistep reaction;
参考文献
Tetrahedron Letters, , p. 4647 - 4650
反应条件
1: zinc chloride / toluene / 15 h / Heating 2: sodium borohydride / methanol / 12 h / 0 °C 3: potassium carbonate / dimethylformamide / 24 h / 20 °C 4: 100 percent / hydrogen; water / 5 percent Pd/C NX-type / methanol / 12 h / 60 °C / 3750.3 Torr View Scheme
参考文献
Kanai, Masatomi; Yasumoto, Manabu; Kuriyama, Yokusu; Inomiya, Kenjin; Katsuhara, Yutaka; Higashiyama, Kimio; Ishii, Akihiro
Organic Letters, 2003 , vol. 5, # 7 p. 1007 - 1010
反应条件
1: toluene-4-sulfonic acid; sodium sulfate / methanol; water / 20 °C 2: trichlorosilane; C23H25N3O2 / ethyl acetate / 5 h / 0 °C View Scheme
参考文献
THE UNIVERSITY OF SHEFFIELD; JONES, Simon; LI, Xianfu
Patent: WO2013/79942 A1, 2013 ;
反应条件
dihydrogen peroxide; trifluoroacetic anhydride in chloroform; water T=0 - 70°C; 6.5 h;
参考文献
MITSUBISHI GAS CHEMICAL COMPANY, INC.
Patent: EP1500641 A1, 2005 ;
Location in patent: Page 11 ;
反应条件
1.1: titanium(IV) isopropylate / tetrahydrofuran / 20 °C / Inert atmosphere 2.1: hydrogen; iodine / di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; C34H28FeNOP / acetone / 24 h / 20 °C / 18751.9 Torr 3.1: hydrogenchloride; water / propan-1-ol / 20 h / 95 °C 3.2: 20 °C / pH 12 View Scheme
参考文献
LEO PHARMA A/S; SØRENSEN, Morten, Dahl; DI FABIO, Romani; POZZAN, Alfonso; CATALANI, Maria, Pia; BLADH, Haakon; FELDING, Jakob
Patent: WO2013/124286 A1, 2013 ;
反应条件
1: toluene-4-sulfonic acid; sodium sulfate / methanol; water / 20 °C 2: trichlorosilane; C23H25N3O2 / ethyl acetate / 5 h / 0 °C View Scheme
参考文献
THE UNIVERSITY OF SHEFFIELD; JONES, Simon; LI, Xianfu
Patent: WO2013/79942 A1, 2013 ;
反应条件
sodium hydroxide; [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2 in isopropyl alcohol
参考文献
Brands, Karel M. Jos; Payack, Joseph F.; Pye, Philip J.
Patent: US2002/52493 A1, 2002 ;
反应条件
C51H57ClFeN2OP2(1+)*BF4(1-); potassium tert-butylate; isopropyl alcohol T=28°C; 0.00277778 h; Catalytic behavior; Reagent/catalyst; enantioselective reaction;
参考文献
Zuo, Weiwei; Lough, Alan J.; Li, Young Feng; Morris, Robert H.
Science, 2013 , vol. 342, # 6162 p. 1080 - 1083
反应条件
sodium hydroxide in isopropyl alcohol
参考文献
Brands, Karel M. Jos; Payack, Joseph F.; Pye, Philip J.
Patent: US2002/52493 A1, 2002 ;
反应条件
dimethylsulfide borane complex; chiral oxazaborolidine in dichloromethane; toluene T=-20°C; Title compound not separated from byproducts;
参考文献
Reichard, Gregory A.; Stengone, Carmine; Paliwal, Sunil; Mergelsberg, Ingrid; Majmundar, Sapna; Wang, Cheng; Tiberi, Robert; McPhail, Andrew T.; Piwinski, John J.; Shih, Neng-Yang
Organic Letters, 2003 , vol. 5, # 23 p. 4249 - 4251
