3,5-双三氟甲基苯乙酮合成路线 （共 44 条）
反应条件
1: With N-methoxyamine hydrochloride; sodium acetate in ethanol; water
18 h; Heating / reflux;
2: With borane-THF in tetrahydrofuran
T=0°C; 18 h; Heating / reflux;
3: With hydrogenchloride in diethyl ether
参考文献
Pineiro, Jose Luis Castro; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John; Yang, Lihu
Patent: US2003/225059 A1, 2003 ;
Location in patent: Page 21 ;
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in diethyl ether; hexane
1 h; Inert atmosphere;
2: 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one in diethyl ether; hexane
T=20°C; Wittig reaction; 24 h; Inert atmosphere;
参考文献
Li, Shengkun; Huang, Kexuan; Cao, Bonan; Zhang, Jiwen; Wu, Wenjun; Zhang, Xumu
Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8573 - 8576
反应条件
sodium t-butanolate; (1,1'-bis(di-tert-butylphosphino)ferrocene)PdCl2 in 1,4-dioxane
T=100°C;
参考文献
Grasa, Gabriela A.; Colacot, Thomas J.
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 522 - 529
反应条件
1: sodium borohydride
2: 5.5 g / lipase CAL-B; 2,6-lutidine / toluene / 68 h / 40 °C
View Scheme
参考文献
Etayo, Pablo; Nunez-Rico, Jose Luis; Fernandez-Perez, Hector; Vidal-Ferran, Anton
Chemistry - A European Journal, 2011 , vol. 17, # 50 p. 13978 - 13982
