1,3,4,5-四氢-吡啶并[4,3-b]吲哚-2,8-二羧酸 2-叔丁酯合成路线 （共 5 条）
反应条件
1: 4-hydrazino-benzoic acid hydrochloride; 4-piperidone-monohydrite, hydrochloride With hydrogenchloride in 1,4-dioxane; water Heating / reflux; 2: di-tert-butyl dicarbonate With sodium hydroxide in methanol T=20°C; pH=~ 9 - 10; 3: With acetic acid in water pH=~ 5;
参考文献
AstraZeneca AB
Patent: WO2006/101434 A1, 2006 ;
Location in patent: Page/Page column 24; 30; 31 ;
WO 2006/101434 A1
反应条件
sodium hydroxide in methanol; water T=20°C; pH=9 - 10;
参考文献
Ferguson, Fleur M.; Fedorov, Oleg; Chaikuad, Apirat; Philpott, Martin; Muniz, Joao R. C.; Felletar, Ildiko; Von Delft, Frank; Heightman, Tom; Knapp, Stefan; Abell, Chris; Ciulli, Alessio
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 10183 - 10187
反应条件
1: hydrogenchloride / 1,4-dioxane; water / Reflux 2: sodium hydroxide View Scheme
参考文献
Cheng, Yun-Xing; Pourashraf, Mehrnaz; Luo, Xuehong; Srivastava, Sanjay; Walpole, Christopher; Salois, Dominic; St-Onge, Stephane; Payza, Kemal; Lessard, Etienne; Yu, Xiao Hong; Tomaszewski, Miroslaw J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1619 - 1624
反应条件
1: hydrogenchloride / 1,4-dioxane / 3 h / |Reflux 2: sodium hydroxide / water; methanol / 20 °C / pH 9 - 10 View Scheme
参考文献
Ferguson, Fleur M.; Fedorov, Oleg; Chaikuad, Apirat; Philpott, Martin; Muniz, Joao R. C.; Felletar, Ildiko; Von Delft, Frank; Heightman, Tom; Knapp, Stefan; Abell, Chris; Ciulli, Alessio
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 10183 - 10187
反应条件
1: hydrogenchloride / 1,4-dioxane / 3 h / |Reflux 2: sodium hydroxide / water; methanol / 20 °C / pH 9 - 10 View Scheme
参考文献
Ferguson, Fleur M.; Fedorov, Oleg; Chaikuad, Apirat; Philpott, Martin; Muniz, Joao R. C.; Felletar, Ildiko; Von Delft, Frank; Heightman, Tom; Knapp, Stefan; Abell, Chris; Ciulli, Alessio
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 10183 - 10187
