反应条件
<b>Multi-step reaction with 8 steps<br /> </b>1.1: 90 percent / methanesulfonic acid / 4 h / 85 - 90 °C<br />2.1: 41 percent / LAH / diethyl ether / 0.25 h / 0 °C<br />3.1: 80 percent / DMAP / tetrahydrofuran / 8 h / 0 °C<br />4.1: 87 percent / DMAP; TEA / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / 20 °C<br />5.1: 100 percent / aq. AcOH / tetrahydrofuran / 3 h / 20 °C<br />6.1: 92 percent / MnO<sub>2</sub> / CH<sub>2</sub>Cl<sub>2</sub> / 5 h<br />7.1: 82 percent / aq. sodium chlorite; sodium phosphate; 30 percent H<sub>2</sub>O<sub>2</sub> / acetonitrile / 2 h / 10 °C<br />8.1: EDC / CH<sub>2</sub>Cl<sub>2</sub> / 0.17 h / 0 °C<br />8.2: 65 percent / DMAP; HOBt / CH<sub>2</sub>Cl<sub>2</sub> / 4 h / 0 - 20 °C<br /> <br />
参考文献
Liao; Hendrata; Sung Yong Bae; Wang Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 8 p. 1138 - 1147
