4,4-二甲基-2-氧唑啉合成路线 （共 29 条）
反应条件
C2H3O2(1-)*C20H30OP(1-)*C20H31OP*Pd(2+); lithium tert-butylate in N,N-dimethyl acetamide
T=100°C; 14 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Barfuesser, Sebastian; Kornhaass, Christoph; Kapdi, Anant R.
Organic Letters, 2011 , vol. 13, # 12 p. 3082 - 3085
反应条件
1: 1.) n-BuLi / 1.) glyme, 0 deg C, 15 min, 2.) reflux, 20 h
2: 1.) diisopropylamine, n-BuLi / 1.) THF, 6 h, reflux, 2.) room temp.
View Scheme
参考文献
Chenard, B. L.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2610 - 2613
反应条件
C2H3O2(1-)*C20H30OP(1-)*C20H31OP*Pd(2+); lithium tert-butylate in N,N-dimethyl acetamide
T=100°C; 14 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Barfuesser, Sebastian; Kornhaass, Christoph; Kapdi, Anant R.
Organic Letters, 2011 , vol. 13, # 12 p. 3082 - 3085
反应条件
3-chloro-benzenecarboperoxoic acid in diethyl ether
T=-20°C; 48 h;
参考文献
Hendrickson, James B.; Pearson, Daniel A.
Tetrahedron Letters, 1983 , vol. 24, # 43 p. 4657 - 4660
反应条件
C2H3O2(1-)*C20H30OP(1-)*C20H31OP*Pd(2+); lithium tert-butylate in N,N-dimethyl acetamide
T=100°C; 14 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Barfuesser, Sebastian; Kornhaass, Christoph; Kapdi, Anant R.
Organic Letters, 2011 , vol. 13, # 12 p. 3082 - 3085
反应条件
1: 1.) n-BuLi / 1.) glyme, 0 deg C, 15 min, 2.) reflux, 20 h
2: 2.) CH3I / 1.) THF, -78 deg C, 25 min, 2.) room temp.
View Scheme
参考文献
Chenard, B. L.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2610 - 2613
反应条件
1: 4,4-dimethyl-Δ2-oxazoline With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.333333 h; Inert atmosphere;
2: With zinc(II) chloride in tetrahydrofuran; diethyl ether; hexane
T=-78 - 0°C; Inert atmosphere;
3: benzoyl chloride Further stages;
参考文献
Degennaro, Leonardo; Capriati, Vito; Carlucci, Claudia; Florio, Saverio; Luisi, Renzo; Nuzzo, Irene; Cuocci, Corrado
Tetrahedron, 2009 , vol. 65, # 42 p. 8745 - 8755
反应条件
Yield given. Multistep reaction;
参考文献
Dondoni, Alessandro; Fantin, Giancarlo; Fogagnolo, Marco; Medici, Alessandro; Pedrini, Paola
Synthesis, 1987 , # 8 p. 693 - 696
反应条件
PCy3*HCl; tri-cyclo-hexyl-phosphine; [RhCl(cis-cyclooctene)2]2 in tetrahydrofuran
T=45°C; 18 h;
参考文献
Wiedemann, Sean H.; Bergman, Robert G.; Ellman, Jonathan A.
Organic Letters, 2004 , vol. 6, # 10 p. 1685 - 1687
