(2-硝基苯基)乙酸甲酯合成路线 （共 35 条）
反应条件
1: With hydrogen in ethyl acetate T=20°C; P=7600.51 Torr; 24 h; Autoclave; 2: in ethyl acetate 6 h; RefluxMolecular sieve;
参考文献
Motoyama, Yukihiro; Kamo, Kazuyuki; Nagashima, Hideo
Organic Letters, 2009 , vol. 11, # 6 p. 1345 - 1348
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate T=0°C; P=735.5 Torr; 4 h; Title compound not separated from byproducts;
参考文献
Motoyama, Yukihiro; Kamo, Kazuyuki; Nagashima, Hideo
Organic Letters, 2009 , vol. 11, # 6 p. 1345 - 1348
反应条件
1.1: 93 percent / K2CO3; 18-crown-6 / acetonitrile / Heating 2.1: O3 / -78 °C 2.2: p-TsOH; Me2S / methanol / 0 - 20 °C 2.3: 98 percent / aq. HClO4 / tetrahydrofuran / 7 h / 0 - 20 °C 3.1: 90 percent / H2 / 5percent Pd/C / methanol / 8 h / 30 °C / 3040.2 Torr View Scheme
参考文献
Bunce; Herron; Johnson; Kotturi
Journal of Organic Chemistry, 2001 , vol. 66, # 8 p. 2822 - 2827
反应条件
1: 48 percent / Na2CO3 / methanol / 20 h / 40 °C 2: 20 percent / Na2CO3 / methanol; H2O / 18 h / Heating View Scheme
参考文献
Frontana-Uribe; Moinet
Acta Chemica Scandinavica, 1999 , vol. 53, # 10 p. 814 - 823
反应条件
15-crown-5; sodium hydride in N,N-dimethyl-formamide T=-4 - 4°C;
参考文献
Neumann, Julia J.; Rakshit, Souvik; Droge, Thomas; Glorius, Frank
Angewandte Chemie, International Edition, 2009 , vol. 48, # 37 p. 6892 - 6895
Angewandte Chemie, 2009 , vol. 121, # 37 p. 7024 - 7027
反应条件
1: 92 percent / K2CO3; 18-crown-6 / acetonitrile / 8 h / Heating 2: aq. NaOH / dioxane / 3 h / 20 °C 3: 5.86 g / K2CO3 / dimethylformamide / 0.75 h / 50 °C 4: O3; Me2S; AcOH / methanol / -78 - 20 °C View Scheme
参考文献
Bunce, Richard A.; Herron, Derrick M.; Ackerman, Matthew L.
Journal of Organic Chemistry, 2000 , vol. 65, # 9 p. 2847 - 2850
反应条件
hydrazine hydrate in ethanol 12 h; Reflux;
参考文献
Frlan, Rok; Kovas, Andreja; Blanot, Didier; Gobec, Stanislav; Pecar, Slavko; Obreza, Ales
Acta Chimica Slovenica, 2011 , vol. 58, # 2 p. 295 - 310
反应条件
1: 62 percent / K2CO3 / H2O / 60 °C
2: 86 percent / 3 Angstroem molecular sieves; paraformaldehyde / toluene / Heating
3: 84 percent / H2 / Pd/C / methanol
View Scheme
参考文献
Selvakumar; Azhagan, A.Malar; Srinivas; Krishna, G.Gopi
Tetrahedron Letters, 2002 , vol. 43, # 50 p. 9175 - 9178
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / 20 °C / |Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 20 °C
3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
CROWN BIOSCIENCE INC. (TAICANG); ZHANG, Deyi; ZHANG, Ruihao; ZHONG, Boyu; SHIH, Chuan
Patent: WO2014/418 A1, 2014 ;
反应条件
1: 22 percent / NBS; benzoyl peroxide / CCl4 / 72 h / Heating
2: 90 percent / dimethylformamide / 2 h
3: 80 percent / aq. HCl; AcOH / 4 h / Heating
4: 88 percent / p-toluenesulfonic acid monohydrate / 8 h / Heating
View Scheme
参考文献
Salerno; Magde; Patron
Journal of Organic Chemistry, 2000 , vol. 65, # 13 p. 3971 - 3981
