4-羟基-3-硝基苯甲醛合成路线 （共 57 条）
反应条件
2: pyridine View Scheme
参考文献
Constantin; L'Ecuyer
Canadian Journal of Chemistry, 1958 , vol. 36, p. 1627,1630
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide T=80°C; 24 h; Inert atmosphere;
参考文献
Zhu, Yuan-Yuan; Wang, Gui-Tao; Li, Zhan-Ting
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 16 p. 3243 - 3250
反应条件
2: pyridine View Scheme
参考文献
Constantin; L'Ecuyer
Canadian Journal of Chemistry, 1958 , vol. 36, p. 1627,1630
反应条件
1.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / |Inert atmosphere 2.1: pyridinium p-toluenesulfonate / dichloromethane / 16 h / 20 °C / |Inert atmosphere 3.1: palladium 10 on activated carbon; hydrogen / methanol / 2 h / 20 °C / |Inert atmosphere 4.1: NaIO3 / acetone; water / 0.17 h / 20 °C / |Inert atmosphere 4.2: 20 h / 20 °C / |Inert atmosphere 5.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 16 h / 20 °C / |Inert atmosphere 6.1: hydrogenchloride / ethanol; water; tetrahydrofuran / 6 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Pasceri, Raffaele; Siegel, David; Ross, David; Moody, Christopher J.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3310 - 3317
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; 2 h; Inert atmosphere;
参考文献
DAIICHI SANKYO COMPANY, LIMITED
Patent: US2011/53974 A1, 2011 ;
Location in patent: Page/Page column 48 ;
反应条件
in propionic acid
1 h; Heating; Further byproducts given;
参考文献
Little, Robert G.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 129 - 133
反应条件
in acetic acid
12 h; Heating;
参考文献
Varma, Rajendra S.; Bahadur, Surendra; Agnihotri, Anil K.
Journal of Chemical & Engineering Data, 1981 , vol. 26, # 1 p. 103 - 104
反应条件
potassium carbonate in acetonitrile
24 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/111046 A2, 2004 ;
Location in patent: Page/Page column 21-22 ;
WO 2004/111046 A2
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20 - 50°C; 96 h;
参考文献
Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
Patent: US2010/324030 A1, 2010 ;
Location in patent: Page/Page column 9 ;
参考文献
Schering Aktiengesellschaft
Patent: US4006243 A1, 1977 ;
