4-羟基-3-硝基苯甲醛合成路线 （共 57 条）
参考文献
Schering Aktiengesellschaft
Patent: US4006243 A1, 1977 ;
反应条件
1: fuming nitric acid / 5 °C
2: N.N-diethyl-aniline; POCl3
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参考文献
Borrows; Clayton; Hems
Journal of the Chemical Society, 1949 , p. Spl. 185, 188
反应条件
1: NaH / tetrahydrofuran; dimethylformamide / 24 h / Heating
2: 96 percent / H2 / Raney nickel / methanol / 23 h / 2482.31 Torr
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参考文献
Lanni Jr., Thomas B.; Greene, Keri L.; Kolz, Christine N.; Para, Kimberly S.; Visnick, Melean; Mobley, James L.; Dudley, David T.; Baginski, Theodore J.; Liimatta, Marya B.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 3 p. 756 - 760
反应条件
2: pyridine
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参考文献
Constantin; L'Ecuyer
Canadian Journal of Chemistry, 1958 , vol. 36, p. 1627,1630
参考文献
Borrows; Clayton; Hems
Journal of the Chemical Society, 1949 , p. Spl. 185, 188
反应条件
nitric acid
T=5 - 10°C;
参考文献
Hodgson; Beard
Journal of the Chemical Society, 1927 , p. 2381
参考文献
Borrows; Clayton; Hems
Journal of the Chemical Society, 1949 , p. Spl. 185, 188
