4-(2-丙炔基)哌啶-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
potassium carbonate in methanol
T=20°C;
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
Location in patent: Paragraph 0546 ;
反应条件
methanol; potassium carbonate in acetonitrile
T=20°C; 17 h;
参考文献
CUBIST PHARMACEUTICALS, INC.; GU, Yu Gui; HE, Yong; YIN, Ning; ALEXANDER, Dylan, C.; CROSS, Jason, B.; METCALF, Chester, A., III.; BUSCH, Robert
Patent: WO2013/149136 A1, 2013 ;
Location in patent: Page/Page column 82; 83 ;
反应条件
n-butyllithium in tetrahydrofuran
参考文献
Merck and Co., Inc.
Patent: US6265434 B1, 2001 ;
US 6265434 B1
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C; 2 h; Product distribution / selectivity;
参考文献
Recordati Ireland Limited
Patent: US2009/42841 A1, 2009 ;
Location in patent: Page/Page column 35 ;
US 20090042841 A1
反应条件
1: diazomethyl-trimethyl-silane With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: 4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester in tetrahydrofuran; hexane
1 h; Product distribution / selectivity;
参考文献
Recordati Ireland Limited
Patent: US2009/42841 A1, 2009 ;
Location in patent: Page/Page column 35 ;
US 20090042841 A1
反应条件
trifluoroacetic acid
T=0 - 20°C; 3 - 12 h;
参考文献
Rieger, Jayson M.; Thompson, Robert D.
Patent: US2007/270373 A1, 2007 ;
Location in patent: Page/Page column 16-17; 17-18 ;
US 20070270373 A1
