2-溴-1-(1-boc-哌啶-4-基)乙酮合成路线 （共 7 条）
反应条件
1: With chloro-trimethyl-silane; lithium hexamethyldisilazane in tetrahydrofuran T=-78 - 0°C; 2: With bromine in tetrahydrofuran T=-78 - 20°C;
参考文献
INOVACIA AB
Patent: WO2009/150144 A1, 2009 ;
Location in patent: Page/Page column 139 ;
WO 2009/150144 A1
反应条件
N-bromosuccinmide; n-butyllithium; triethylamine; diisopropylamine in tetrahydrofuran; hexane; methyloxirane
参考文献
US6248755 B1, ;
US 6248755 B1
反应条件
1.1: DCC; DMAP 2.1: MeMgBr / diethyl ether 2.2: LDA; TMSCl 2.3: NBS View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 8 p. 2129 - 2134
反应条件
1.1: diethyl ether 2.1: LDA; TMSCl 2.2: NBS View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 13 p. 3419 - 3424
反应条件
ammonia T=40°C; P=10032.9 Torr; 20 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/41279 A1, 2004 ;
Location in patent: Page/Page column 71 ;
WO 2004/041279 A1
反应条件
in tetrahydrofuran
T=60°C; 96 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/41279 A1, 2004 ;
Location in patent: Page/Page column 70 ;
WO 2004/041279 A1
反应条件
potassium carbonate in ethanol
T=60°C; 8 h;
参考文献
SYNGENTA PARTICIPATIONS AG; LAMBERTH, Clemens; SULZER-MOSSE, Sarah; CEDERBAUM, Fredrik Emil Malcolm
Patent: WO2013/56915 A1, 2013 ;
Location in patent: Page/Page column 34 ;
