(2-氨基苯并噻唑-6-基)乙酸合成路线 （共 9 条）
反应条件
bromine in water; acetic acid T=20°C; 4 h;
参考文献
Bhagwat, Shripad; Chao, Qi; Grotzfeld, Robert M.; Patel, Hitesh K.; Sprankle, Kelly G.
Patent: US2007/232604 A1, 2007 ;
Location in patent: Page/Page column 42 ;
反应条件
bromine in chloroform
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 16, p. 605 - 609
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 16, p. 605 - 609
反应条件
1: Br2, AcOH 2: aq. H2SO4 View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 16, p. 605 - 609
反应条件
bromine; acetic acid
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 16, p. 605 - 609
反应条件
1: 1.) 50percent KOH; 2.) conc. HCl / 1.) reflux, 80 h; 2.) 0 - 5 deg C 2: 65 percent / ethane-1,2-diol / 7 h / 80 - 85 °C 3: 1.) NH4OH; 2.) conc. HCl / 1.) 60 - 65 deg C, 12 h; 2.) 0 - 5 deg C 4: 68 percent / 47percent HBr, AcOH / 10 h / Heating View Scheme
参考文献
Mashraqui, Sabir H.; Nivalkar, Kishor R.
Tetrahedron Letters, 1997 , vol. 38, # 25 p. 4487 - 4488
反应条件
1: 1.) 50percent KOH; 2.) conc. HCl / 1.) reflux, 80 h; 2.) 0 - 5 deg C 2: 65 percent / ethane-1,2-diol / 7 h / 80 - 85 °C 3: 1.) NH4OH; 2.) conc. HCl / 1.) 60 - 65 deg C, 12 h; 2.) 0 - 5 deg C View Scheme
参考文献
Mashraqui, Sabir H.; Nivalkar, Kishor R.
Tetrahedron Letters, 1997 , vol. 38, # 25 p. 4487 - 4488
反应条件
1: With sulfuric acid in water
72 h; Molecular sieveHeating / reflux;
2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2007/75567 A1, 2007 ;
Location in patent: Page/Page column 100 -101 ;
WO 2007/075567 A1
反应条件
1: With hydrogenchloride in 1,4-dioxane
T=75°C; 9 h;
2: With sodium hydroxide in water
pH=9;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2007/16392 A2, 2007 ;
Location in patent: Page/Page column 57 ;
WO 2007/016392 A2
