(1-甲基-1H-咪唑-2-基)苯甲酮合成路线 （共 19 条）
反应条件
1: I2, Mg / 1.) THF, 0 deg C, 2.) THF, 0 deg C, 30 min 2: 1.) (CH3)2SO4, 2.) 10percent K2CO3 / 1.) ethyl acetate, reflux, 2 h, 2.) benzene, 80 deg C, 2 h 3: p-TsOH / benzene / 2 h / Heating View Scheme
参考文献
Hayakawa, Satoshi; Michiue, Tohru; Okamoto, Masao; Hatakeyama, Shoko; Ohta, Shunsaku
Heterocycles, 1988 , vol. 27, # 2 p. 457 - 474
反应条件
1: 93.1 percent / Mg / diethyl ether / 0.75 h / 0 °C 2: 1.) (CH3)2SO4, 2.) 10percent K2CO3 / 1.) ethyl acetate, reflux, 2 h, 2.) benzene, 80 deg C, 2 h View Scheme
参考文献
Hayakawa, Satoshi; Michiue, Tohru; Okamoto, Masao; Hatakeyama, Shoko; Ohta, Shunsaku
Heterocycles, 1988 , vol. 27, # 2 p. 457 - 474
反应条件
sodium hydroxide in ethanol T=90°C; 30 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 34, # 12 p. 4916 - 4926
反应条件
1: 1.) 1.6 M n-butyllithium / 1.) hexane, THF, r.t., 2 h; 2.) 60 deg C, 2 h 2: hexane; tetrahydrofuran; dimethylformamide / 3 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 34, # 12 p. 4916 - 4926
反应条件
1: I2, Mg / 1.) THF, 0 deg C, 2.) THF, 0 deg C, 30 min 2: 1.) (CH3)2SO4, 2.) 10percent K2CO3 / 1.) ethyl acetate, reflux, 2 h, 2.) benzene, 80 deg C, 2 h 3: p-TsOH / benzene / 2 h / Heating View Scheme
参考文献
Hayakawa, Satoshi; Michiue, Tohru; Okamoto, Masao; Hatakeyama, Shoko; Ohta, Shunsaku
Heterocycles, 1988 , vol. 27, # 2 p. 457 - 474
反应条件
1: 66.7 percent / ethyl acetate / 5 h / 95 - 100 °C
2: CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Ohta, Shunsaku; Hayakawa, Satoshi; Okamoto, Masao
Tetrahedron Letters, 1984 , vol. 25, # 49 p. 5681 - 5684
反应条件
1: 66.7 percent / ethyl acetate / 5 h / 95 - 100 °C
2: 71.6 percent Chromat. / triethylamine / CH2Cl2 / 1 h
View Scheme
参考文献
Ohta, Shunsaku; Hayakawa, Satoshi; Moriwaki, Hiroki; Harada, Suzumi; Okamoto, Masao
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 12 p. 4916 - 4926
反应条件
1: 1.) 1.6 M n-butyllithium / 1.) hexane, THF, r.t., 2 h; 2.) 60 deg C, 2 h
2: hexane; tetrahydrofuran; H2O / 3 h / Ambient temperature
View Scheme
参考文献
Ohta, Shunsaku; Hayakawa, Satoshi; Okamoto, Masao
Tetrahedron Letters, 1984 , vol. 25, # 49 p. 5681 - 5684
反应条件
sodium hydroxide in ethanol
T=90°C; 30 h;
参考文献
Ohta, Shunsaku; Hayakawa, Satoshi; Moriwaki, Hiroki; Harada, Suzumi; Okamoto, Masao
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 12 p. 4916 - 4926
