1-甲基咪唑-2-甲酸乙酯合成路线 （共 17 条）
反应条件
triethylamine in acetonitrile T=-25 - 20°C; 36 h;
参考文献
Baird, Eldon E.; Dervan, Peter B.
Journal of the American Chemical Society, 1996 , vol. 118, # 26 p. 6141 - 6146
反应条件
1: 1-methyl-1H-imidazole With n-butyllithium in tetrahydrofuran; hexane T=0°C; 2 h; 2: formic acid ethyl ester in tetrahydrofuran; hexane T=-78°C; 3 h; 3: With ethanol; iodine; potassium carbonate in tetrahydrofuran; hexane T=-78 - 20°C; 14 h;
参考文献
Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 24 p. 4701 - 4709
反应条件
in tetrahydrofuran; hexane 12 h; Ambient temperature; Yield given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 3 p. 239 - 244
反应条件
1: 46.5 percent / conc. H2SO4, 100percent HNO3 / 0.83 h / 95 °C 2: 95 percent / NaOH / H2O / 0.25 h / Heating 3: oxalyl chloride / acetonitrile; CHCl3 / Heating View Scheme
参考文献
Krowicki, Krzysztof; Lown, J. William
Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3493 - 3501
反应条件
ammonium hydroxide in methanol 1) 0 deg C, 2 h; 2) room temperature, overnight;
参考文献
Bakhtiar, Cuross; Smith, Edward H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 3 p. 239 - 244
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Shirley; Alley
Journal of the American Chemical Society, 1957 , vol. 79, p. 4922,4926
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=-40°C; Claisen condensation; 0.333333 h; Inert atmosphere;
参考文献
Venkat Ragavan; Vijayakumar; Rajesh; Palakshi Reddy; Karthikeyan; Suchetha Kumari
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4193 - 4197
反应条件
sulfuric acid; nitric acid T=95°C; 0.833333 h;
参考文献
Krowicki, Krzysztof; Lown, J. William
Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3493 - 3501
反应条件
sulfuric acid; nitric acid T=0 - 20°C; 1.5 h; Heating / reflux;
参考文献
UNIVERSITY OF WESTERN SYDNEY
Patent: WO2005/33077 A1, 2005 ;
Location in patent: Page/Page column 53-54 ;
反应条件
sulfuric acid; nitric acid T=95°C; 0.833333 h;
参考文献
Journal of Organic Chemistry, , vol. 52, # 16 p. 3493 - 3501
