1-甲基咪唑-2-甲酸乙酯合成路线 （共 17 条）
参考文献
Shirley; Alley
Journal of the American Chemical Society, 1957 , vol. 79, p. 4922,4926
反应条件
1: 22 percent / HNO3, H2SO4 / 0.83 h / Heating 2: H2 / 10percent Pd/C / ethanol; ethyl acetate / 48 h / 836 Torr View Scheme
参考文献
Baird, Eldon E.; Dervan, Peter B.
Journal of the American Chemical Society, 1996 , vol. 118, # 26 p. 6141 - 6146
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Shirley; Alley
Journal of the American Chemical Society, 1957 , vol. 79, p. 4922,4926
反应条件
1: ethyl 1-methyl-imidazole-2-carboxylate With sodium hydroxide; water 1 h; Heating / reflux; 2: C5H5N2O2(1-)*Na(1+) With hydrogenchloride in water T=5 - 50°C; pH=2;
参考文献
MERCK and CO., INC.
Patent: WO2004/58763 A1, 2004 ;
Location in patent: Page 43 ;
WO 2004/058763 A1
反应条件
1: With sodium hydroxide in water 1 h; Reflux; 2: With hydrogenchloride in water pH=2;
参考文献
Jimenez-Balsa, Adrian; Dodero, Veronica I.; Mascarenas, Jose L.
Tetrahedron, 2013 , vol. 69, # 36 p. 7847 - 7853
反应条件
1: 84 percent / aq. NH3 / methanol / 1) 0 deg C, 2 h; 2) room temperature, overnight
2: 46 percent / POCl3, pyridine / toluene / 2 h / Heating
View Scheme
参考文献
Bakhtiar, Cuross; Smith, Edward H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 3 p. 239 - 244
反应条件
n-butyllithium
1.) diethyl ether, RT, 2.) diethyl ether, from -60 deg C to RT, 3 h; Yield given. Multistep reaction;
参考文献
Canty, Allan J.; George, Edwin E.; Lee, Christopher V.
Australian Journal of Chemistry, 1983 , vol. 36, # 2 p. 415 - 418
