1-甲基-2-(三氯乙酰基)咪唑合成路线 （共 10 条）
反应条件
1: 56 percent / nitric acid; sulfuric acid / acetic anhydride / 12 h / -40 °C 2: 95 percent / ethanol View Scheme
参考文献
Nishiwaki, Eiji; Tanaka, Shigeaki; Lee, Hideaki; Shibuya, Masayuki
Heterocycles, 1988 , vol. 27, # 8 p. 1945 - 1952
反应条件
1: 65 percent / HNO3; H2SO4; acetic anydride / 24 h / 0 - 20 °C 2: 70 percent / methanol / 3 h 3: 91 percent / hydrogen / Pd/C / methanol / 31 h 4: 87 percent / potassium tert-butoxide; H2O / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Wurtz, Nicholas R.; Turner, James M.; Baird, Eldon E.; Dervan, Peter B.
Organic Letters, 2001 , vol. 3, # 8 p. 1201 - 1203
反应条件
1: N-bromosuccinmide / tetrahydrofuran / 24 h / 35 °C / Cooling with ice 2: ethanol / 4 h / 10 - 35 °C View Scheme
反应条件
1: 65 percent / HNO3; H2SO4; acetic anydride / 24 h / 0 - 20 °C 2: 70 percent / methanol / 3 h View Scheme
参考文献
Jaramillo, David; Liu, Qi; Aldrich-Wright, Janice; Tor, Yitzhak
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8151 - 8153
反应条件
sulfuric acid; nitric acid; acetic anhydride T=0 - 20°C; 24 h;
参考文献
Jaramillo, David; Liu, Qi; Aldrich-Wright, Janice; Tor, Yitzhak
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8151 - 8153
反应条件
sulfuric acid; nitric acid in acetic anhydride Ambient temperature;
参考文献
Nishiwaki, Eiji; Tanaka, Shigeaki; Lee, Hideaki; Shibuya, Masayuki
Heterocycles, 1988 , vol. 27, # 8 p. 1945 - 1952
反应条件
1: 2-trichloroacetyl-N-methyl-1H-imidazole With N-bromosuccinmide in tetrahydrofuran
T=-10 - 20°C; 14 h;
2: methanol With sodium hydride
T=75°C; 1 h;
参考文献
AMGEN INC.
Patent: WO2009/75874 A1, 2009 ;
Location in patent: Page/Page column 132 ;
WO 2009/075874 A1
反应条件
1: N-bromosuccinmide / tetrahydrofuran / 18 h / -10 - 25 °C
2: methanol / 0.33 h / 25 °C
View Scheme
参考文献
Billedeau, Roland Joseph; Kondru, Rama K.; Lopez-Tapia, Francisco Javier; Lou, Yan; Owens, Timothy D.; Qian, Yimin; So, Sung-Sau; Thakkar, Kshitij C.; Wanner, Jutta
Patent: US2012/295885 A1, 2012 ;
反应条件
1: 65 percent / HNO3; H2SO4; acetic anydride / 24 h / 0 - 20 °C
2: 70 percent / methanol / 3 h
3: 91 percent / hydrogen / Pd/C / methanol / 31 h
View Scheme
参考文献
Jaramillo, David; Liu, Qi; Aldrich-Wright, Janice; Tor, Yitzhak
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8151 - 8153
反应条件
N-bromosuccinmide in tetrahydrofuran
T=-10 - 20°C; 14 h;
参考文献
SPIROGEN LIMITED
Patent: WO2005/85177 A2, 2005 ;
Location in patent: Page/Page column 61-62 ;
