2-(溴甲基)-1,3-二甲基-5-(苯基甲氧基)-苯合成路线 （共 7 条）
反应条件
phosphorus tribromide in tetrahydrofuran T=0°C; 2 h;
参考文献
Aicher, Thomas Daniel; Anzeveno, Peter Biagio; Li, Renhua; Krasutsky, Alexei Pavlovych; Mabry, Thomas Edward; Saeed, Ashraf; Snyder, Nancy June; Stephenson, Gregory Alan; Tian, Hongqi; Wallace, Owen Brendan; Winneroski, JR., Leonard Larry; Xu, Yanping
Patent: US2009/111800 A1, 2009 ;
Location in patent: Page/Page column 39 ;
US 20090111800 A1
反应条件
1: 92 percent / LiALH4 / tetrahydrofuran / 4 h / Heating 2: 83 percent / PBr3; pyridine / diethyl ether / -78 - 20 °C View Scheme
参考文献
Lin, Li; Fu, Xu; Ma, Xiaojuan; Zhang, Jinlong; Wang, Rui
Synlett, 2012 , vol. 23, # 17 p. 2559 - 2563,5
Title/Abstract Full Text Show Details
Lin, Li; Fu, Xu; Ma, Xiaojuan; Zhang, Jinlong; Wang, Rui
Synlett, 2012 , vol. 23, # 17 p. 2559 - 2563
反应条件
1: potassium carbonate / acetone / 3 h / |Reflux 2: sodium tetrahydroborate / methanol / 0 - 20 °C 3: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0 °C View Scheme
参考文献
Lin, Li; Fu, Xu; Ma, Xiaojuan; Zhang, Jinlong; Wang, Rui
Synlett, 2012 , vol. 23, # 17 p. 2559 - 2563,5
Title/Abstract Full Text Show Details
Lin, Li; Fu, Xu; Ma, Xiaojuan; Zhang, Jinlong; Wang, Rui
Synlett, 2012 , vol. 23, # 17 p. 2559 - 2563
反应条件
1: potassium carbonate / acetone / 3 h / |Reflux 2: sodium tetrahydroborate / methanol / 0 - 20 °C 3: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0 °C View Scheme
参考文献
Lin, Li; Fu, Xu; Ma, Xiaojuan; Zhang, Jinlong; Wang, Rui
Synlett, 2012 , vol. 23, # 17 p. 2559 - 2563,5
Title/Abstract Full Text Show Details
Lin, Li; Fu, Xu; Ma, Xiaojuan; Zhang, Jinlong; Wang, Rui
Synlett, 2012 , vol. 23, # 17 p. 2559 - 2563
反应条件
1.1: NaOH / methanol / 2 h / 0 °C 1.2: 97 percent / 1,2-dimethoxy-ethane / 24 h / 35 °C 2.1: I2; Mg / tetrahydrofuran / 1 h / Heating 2.2: 90 percent / tetrahydrofuran / 0 - 20 °C 3.1: 92 percent / LiALH4 / tetrahydrofuran / 4 h / Heating 4.1: 83 percent / PBr3; pyridine / diethyl ether / -78 - 20 °C View Scheme
参考文献
Tang, Xuejun; Soloshonok, Vadim A.; Hruby, Victor J.
Tetrahedron Asymmetry, 2000 , vol. 11, # 14 p. 2917 - 2925
反应条件
1.1: I2; Mg / tetrahydrofuran / 1 h / Heating 1.2: 90 percent / tetrahydrofuran / 0 - 20 °C 2.1: 92 percent / LiALH4 / tetrahydrofuran / 4 h / Heating 3.1: 83 percent / PBr3; pyridine / diethyl ether / -78 - 20 °C View Scheme
参考文献
Tang, Xuejun; Soloshonok, Vadim A.; Hruby, Victor J.
Tetrahedron Asymmetry, 2000 , vol. 11, # 14 p. 2917 - 2925
反应条件
1.1: NaOH / methanol / 2 h / 0 °C 1.2: 97 percent / 1,2-dimethoxy-ethane / 24 h / 35 °C 2.1: I2; Mg / tetrahydrofuran / 1 h / Heating 2.2: 90 percent / tetrahydrofuran / 0 - 20 °C 3.1: 92 percent / LiALH4 / tetrahydrofuran / 4 h / Heating 4.1: 83 percent / PBr3; pyridine / diethyl ether / -78 - 20 °C View Scheme
参考文献
Tang, Xuejun; Soloshonok, Vadim A.; Hruby, Victor J.
Tetrahedron Asymmetry, 2000 , vol. 11, # 14 p. 2917 - 2925
