(R)-1-苄基-5-甲基哌嗪-2-酮合成路线 （共 4 条）
反应条件
hydrogen; palladium dihydroxide in methanol Hydrogenolysis; 4 h;
参考文献
Dinsmore; Zartman
Tetrahedron Letters, 2000 , vol. 41, # 33 p. 6309 - 6312
反应条件
1: sat. NaHCO3 / ethyl acetate / 0.33 h / 0 °C 2: 98 percent / DMSO; (COCl)2; Et3N / CH2Cl2 / 0.75 h / -78 - 20 °C 3: 4 Angstroem molecular sieves; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 48 h / 0 - 20 °C 4: 91 percent / hydrogen / Pd(OH)2/C / methanol / 4 h View Scheme
参考文献
Dinsmore; Zartman
Tetrahedron Letters, 2000 , vol. 41, # 33 p. 6309 - 6312
反应条件
1: acetonitrile / 0.5 h 2: sat. NaHCO3 / ethyl acetate / 0.33 h / 0 °C 3: 98 percent / DMSO; (COCl)2; Et3N / CH2Cl2 / 0.75 h / -78 - 20 °C 4: 4 Angstroem molecular sieves; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 48 h / 0 - 20 °C 5: 91 percent / hydrogen / Pd(OH)2/C / methanol / 4 h View Scheme
参考文献
Dinsmore; Zartman
Tetrahedron Letters, 2000 , vol. 41, # 33 p. 6309 - 6312
反应条件
1: 4 Angstroem molecular sieves; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 48 h / 0 - 20 °C 2: 91 percent / hydrogen / Pd(OH)2/C / methanol / 4 h View Scheme
参考文献
Dinsmore; Zartman
Tetrahedron Letters, 2000 , vol. 41, # 33 p. 6309 - 6312
