2-甲基-3-喹啉羧酸甲酯合成路线 （共 22 条）
反应条件
1: 55 percent / LAH / tetrahydrofuran / 1 h / 0 °C 2: 90 percent / MCPBA / acetonitrile / 12 h 3: 75 percent / 1.5 h / 130 °C 4: 80 percent / K2CO3 / methanol; H2O / 0.5 h / 20 °C 5: 80 percent / triethylamine / benzene / 2 h / -5 °C View Scheme
参考文献
Chavan, Subhash P.; Pasupathy; Sivappa; Venkatraman
Synthetic Communications, 2004 , vol. 34, # 17 p. 3099 - 3110
反应条件
hydrazine in methanol 2 h; Heating;
参考文献
Kiselyov, Alexander S.; Semenova, Marina; Semenov, Victor V.; Milligan, Daniel
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1913 - 1919
反应条件
manganese(IV) oxide in ethanol
Reflux;
参考文献
Rachakonda, Venkatesham; Alla, Manjula; Kotipalli, Sudha Sravanti; Ummani, Ramesh
European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 536 - 547
反应条件
hydrogen; palladium on activated charcoal in methanol
T=30°C; P=760.051 Torr; 3 h;
参考文献
Bunce, Richard A.; Nago, Takahiro; Sonobe, Nathan
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 5 p. 1059 - 1064
反应条件
water
T=70°C; Friedlaender reaction; 3 h;
参考文献
Shen, Qiang; Wang, Limin; Yu, Jianjun; Liu, Mingtao; Qiu, Jun; Fang, Lei; Guo, Fenglou; Tang, Jun
Synthesis, 2012 , vol. 44, # 3 art. no. H96411SS, p. 389 - 392
反应条件
tin(ll) chloride; zinc(II) chloride in ethanol
T=70°C; Friedlaender Quinoline Synthesis; Inert atmosphereMolecular sieve;
参考文献
Lenoci, Alessia; Tomassi, Stefano; Conte, Mariarosaria; Benedetti, Rosaria; Rodriguez, Veronica; Carradori, Simone; Secci, Daniela; Castellano, Sabrina; Sbardella, Gianluca; Filetici, Patrizia; Novellino, Ettore; Altucci, Lucia; Rotili, Dante; Mai, Antonello
ChemMedChem, 2014 , vol. 9, # 3 p. 542 - 548
反应条件
hydrogenchloride in water
1 h; Heating;
参考文献
Hamada, Yoshiki; Sugiura, Michiharu; Hirota, Minoru
Tetrahedron Letters, 1981 , vol. 22, # 30 p. 2893 - 2894
反应条件
hydrogenchloride in water
1 h; Heating;
参考文献
Hamada, Yoshiki; Sugiura, Michiharu; Hirota, Minoru
Tetrahedron Letters, 1981 , vol. 22, # 30 p. 2893 - 2894
反应条件
2: 89 percent Chromat. / bromine / Ambient temperature
3: 79 percent Chromat. / 50percent aq. sodium hydroxide / 0.5 h / Ambient temperature
4: 62 percent / hydrogen chloride / H2O / 1 h / Heating
View Scheme
参考文献
Hamada, Yoshiki; Sugiura, Michiharu; Hirota, Minoru
Tetrahedron Letters, 1981 , vol. 22, # 30 p. 2893 - 2894
反应条件
1: 89 percent Chromat. / bromine / Ambient temperature
2: 79 percent Chromat. / 50percent aq. sodium hydroxide / 0.5 h / Ambient temperature
3: 62 percent / hydrogen chloride / H2O / 1 h / Heating
View Scheme
参考文献
Hamada, Yoshiki; Sugiura, Michiharu; Hirota, Minoru
Tetrahedron Letters, 1981 , vol. 22, # 30 p. 2893 - 2894
