5-氨基-噻唑并[4,5-d]嘧啶-2,7(3H,6H)-二酮合成路线 （共 3 条）
反应条件
1: NaNO2, HCl / aq. NaOH; H2O 2: aq. NaOH View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 18, p. 2478 - 2484
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 18, p. 2478 - 2484
反应条件
1: 1.) HMDS, (NH4)2SO4, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) pyridine, reflux, 4 h, 2.) acetonitrile, RT, 16 h 2: 46 percent / tert-butyl nitrite / tetrahydrofuran / 50 - 60 °C 3: 57 percent / ammonia / methanol / 14 h / 90 °C View Scheme
参考文献
Nagahara; Anderson; Kini; Dalley; Larson; Smee; Jin; Sharma; Jolley; Robins; Cottam
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 407 - 415
