噻唑并[4,5-d]嘧啶-2,7-二胺合成路线 （共 5 条）
反应条件
bromine; acetic acid
参考文献
Maggiolo; Hitchings
Journal of the American Chemical Society, 1951 , vol. 73, p. 4226
反应条件
in formic acid; N,N-dimethyl-formamide 10 h; Heating;
参考文献
Sherif; Youssef; Mobarak; Abdel-Fattah
Tetrahedron, 1993 , vol. 49, # 42 p. 9561 - 9572
反应条件
in formic acid; N,N-dimethyl-formamide 10 h; Heating;
参考文献
Sherif; Youssef; Mobarak; Abdel-Fattah
Tetrahedron, 1993 , vol. 49, # 42 p. 9561 - 9572
参考文献
Baker; Chatfield
Journal of the Chemical Society. Perkin transactions 1, 1970 , vol. 18, p. 2478 - 2484
反应条件
1: 34 percent / 1.) 1 N, NaOH, sodium nitrite, 2.) aq. HCl, LiCl / 1.) 55 deg C, 2.) 45 deg C, 15 min 2: 88 percent / NaSH*xH2O / dimethylformamide / 1.) 0 deg C, overnight, 2.) RT, 2 h 3: 74 percent / 1 N NaOH, 30percent H2O2 / H2O / 1.) RT, 1 h, 2.) 70 deg C, 1 h View Scheme
参考文献
Nagahara; Anderson; Kini; Dalley; Larson; Smee; Jin; Sharma; Jolley; Robins; Cottam
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 407 - 415
