4-吗啉-4-基-1,2,5-三唑-3-酮合成路线 （共 9 条）
反应条件
sodium hydroxide in dimethyl sulfoxide
参考文献
Rosenbaum, Anton I.; Cosner, Casey C.; Mariani, Christopher J.; Maxfield, Frederick R.; Wiest, Olaf; Helquist, Paul
Journal of Medicinal Chemistry, 2010 , vol. 53, # 14 p. 5281 - 5289
反应条件
oxygen UV-irradiation;
参考文献
Pharmazie, , vol. 58, # 8 p. 551 - 553
反应条件
morpholine; hydrogenchloride 1.) 110-120 deg C, 7.5 h, 2.) CHCl3; Yield given. Multistep reaction;
参考文献
Bodor, Nicholas; ElKoussi, Alaaeldin; Kano, Masanobu; Nakamura, Toshio
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 100 - 106
反应条件
1: 95 percent / potassium tert-butoxide / tetrahydrofuran / 5 h / 25 °C 2: acetic acid / (S,S)-salen-cobalt(II) / tetrahydrofuran; H2O / 8 h / 0 - 20 °C 3: 66 percent / KI / 72 h / Heating View Scheme
参考文献
Bredikhina; Savel'ev; Bredikhin
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 2 p. 213 - 219
反应条件
in dimethyl sulfoxide 96 h; Ambient temperature;
参考文献
Weinstock; Mulvey; Tull
Journal of Organic Chemistry, 1976 , vol. 41, # 19 p. 3121 - 3124
反应条件
1: 95 percent / potassium tert-butoxide / tetrahydrofuran / 5 h / 25 °C 2: acetic acid / (S,S)-salen-cobalt(II) / tetrahydrofuran; H2O / 8 h / 0 - 20 °C 3: 66 percent / KI / 72 h / Heating 4: tetrahydrofuran / 1 h / 25 °C View Scheme
参考文献
Narina, Srinivasarao V.; Sudalai, Arumugam
Tetrahedron, 2007 , vol. 63, # 14 p. 3026 - 3030
反应条件
morpholine; hydrogenchloride 1.) 110-120 deg C, 7.5 h, 2.) CHCl3; Yield given. Multistep reaction;
参考文献
Bodor, Nicholas; ElKoussi, Alaaeldin; Kano, Masanobu; Nakamura, Toshio
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 100 - 106
参考文献
Belanger
Canadian Journal of Chemistry, 1978 , vol. 56, # 5 p. 722 - 724
反应条件
potassium tert-butylate in tetrahydrofuran
T=25°C; 5 h;
参考文献
Narina, Srinivasarao V.; Sudalai, Arumugam
Tetrahedron, 2007 , vol. 63, # 14 p. 3026 - 3030
