1-BOC-3-羟甲基哌嗪合成路线 （共 5 条）
反应条件
sodium hydroxide in ethanol 16 h; Reflux;
参考文献
Matsumoto, Takahiro; Kamo, Izumi; Nomura, Izumi
Patent: US2009/318412 A1, 2009 ;
Location in patent: Page/Page column 34-35 ;
US 20090318412 A1
反应条件
sodium hydroxide in ethanol; water T=70°C; 1 h;
参考文献
WO2007/146066 A2, ;
Page/Page column 83 ;
反应条件
lithium borohydride in tetrahydrofuran
反应条件
1: 3-hydroxymethylpiperazine-1-carboxylic acid tert-butyl ester With sodium hydride in tetrahydrofuran; mineral oil T=0°C; 0.25 h; 2: methyl iodide in tetrahydrofuran; mineral oil T=0 - 20°C;
参考文献
INCYTE CORPORATION; RODGERS, James, D.; LI, Yun-Long; SHEPARD, Stacey; WANG, Haisheng
Patent: WO2011/28685 A1, 2011 ;
Location in patent: Page/Page column 142 ;
WO 2011/028685 A1
反应条件
in tetrahydrofuran; water 1 h;
参考文献
CRITICAL THERAPEUTICS, INC.
Patent: WO2007/146066 A2, 2007 ;
Location in patent: Page/Page column 83 ;
