4-溴-2-羟基苯乙酮合成路线

参考文献

NOVARTIS AG; IRM LLC, a Delaware Limited Liability Company; CHEN, Bei; FAIRHURST, Robin, Alec; FLOERSHEIMER, Andreas; FURET, Pascal; JIANG, Songchun; LU, Wenshuo; MARSILJE, Thomas, H.; VAUPEL, Andrea
Patent: WO2011/64211 A1, 2011 ;
WO 2011/064211 A1

30186-18-64-溴-2-羟基苯乙酮

82305-04-26-溴-2,2-二甲基-2H-苯并吡喃

参考文献

Buckle, Derek R.; Arch, Jonathon R. S.; Fenwick, Ashley E.; Houge-Frydrych, Catherine S. V.; Pinto, Ivan L.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3028 - 3034

30186-18-64-溴-2-羟基苯乙酮+

74-88-4甲基碘

89368-12-74-溴-2-甲氧基苯乙酮

参考文献

Novak, Jiri; Salemink, Cornelis A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2867 - 2871

30186-18-64-溴-2-羟基苯乙酮+

77-78-1硫酸二甲酯

89368-12-74-溴-2-甲氧基苯乙酮

参考文献

Wang, Chen; Dong, Jinyun; Zhang, Yanmin; Wang, Fang; Gao, Hongping; Li, Pengfei; Wang, Sicen; Zhang, Jie
MedChemComm, 2013 , vol. 4, # 11 p. 1434 - 1438

30186-18-64-溴-2-羟基苯乙酮

89384-00-9

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Novak, Jiri; Salemink, Cornelis A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2867 - 2871

30186-18-64-溴-2-羟基苯乙酮

90772-69-3

参考文献

CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.
Patent: WO2013/75084 A1, 2013 ;

30186-18-64-溴-2-羟基苯乙酮+

79099-07-3N-叔丁氧羰基-4-哌啶酮

936648-38-3N-Boc-7-溴-4-氧代-3,4-二氢-1H-螺[色烯-2,4-哌啶]

参考文献

Varasi, Mario; Thaler, Florian; Abate, Agnese; Bigogno, Chiara; Boggio, Roberto; Carenzi, Giacomo; Cataudella, Tiziana; Dal Zuffo, Roberto; Fulco, Maria Carmela; Rozio, Marco Giulio; Mai, Antonello; Dondio, Giulio; Minucci, Saverio; Mercurio, Ciro
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 3051 - 3064

67-56-1甲醇+

201230-82-2+

30186-18-64-溴-2-羟基苯乙酮

478169-69-6

参考文献

BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
Location in patent: Paragraph 0175 ;

30186-18-64-溴-2-羟基苯乙酮

5213-16-1

参考文献

Novak, Jiri; Salemink, Cornelis A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2867 - 2871