1-(对甲苯基)-1H-吡咯-2-甲醛合成路线 （共 8 条）
反应条件
acetic acid in N,N-dimethyl-formamide; trichlorophosphate
参考文献
US5175180 A1, ;
US 5175180 A
参考文献
US5187271 A1, ;
US 5187271 A
反应条件
trichlorophosphate T=110 - 120°C; 3 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 1 p. 101 - 110
反应条件
hydrogenchloride in ethanol 5 h; Heating;
参考文献
Pina, M. del' K.; Budylin, V. A.; Rodriges, M.; Terent'ev, P. B.; Bundel', Yu. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 2 p. 142 - 146
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , vol. 25, # 2 p. 180 - 184
反应条件
1: 74 percent / CH3COOH / 2 h / Heating 2: POCl3 / 3 h / 110 - 120 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 1 p. 101 - 110
反应条件
1: 1.) H2NOH*HCl/Na2CO3, 2.) Ac2O / 1.) MeOH, H2O, reflux, 3 h, 2.) reflux, 3 h 2: KOH / ethane-1,2-diol / 4 h / 167 °C 3: SOCl2 / 4 h / 25 °C 4: 16 h / 25 °C View Scheme
参考文献
Bovy; Reitz; Collins; Chamberlain; Olins; Corpus; McMahon; Palomo; Koepke; Smits; McGraw; Gaw
Journal of Medicinal Chemistry, 1993 , vol. 36, # 1 p. 101 - 110
反应条件
1: 1.) H2NOH*HCl/Na2CO3, 2.) Ac2O / 1.) MeOH, H2O, reflux, 3 h, 2.) reflux, 3 h 2: KOH / ethane-1,2-diol / 4 h / 167 °C 3: SOCl2 / 4 h / 25 °C 4: 16 h / 25 °C 5: 2.5 g / N-bromosuccinimide, 2,2'-azobisisobutyronitrile / CCl4 / 19 h / Heating View Scheme
参考文献
Bovy; Reitz; Collins; Chamberlain; Olins; Corpus; McMahon; Palomo; Koepke; Smits; McGraw; Gaw
Journal of Medicinal Chemistry, 1993 , vol. 36, # 1 p. 101 - 110
反应条件
hydroxylamine hydrochloride; acetic anhydride; sodium carbonate 1.) MeOH, H2O, reflux, 3 h, 2.) reflux, 3 h; Yield given. Multistep reaction;
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5389641 A1, 1995 ;
US 5389641 A
