2-(氨基甲基)-1,3-噻唑-4-甲腈合成路线 （共 6 条）
反应条件
triphenylphosphine in tetrahydrofuran; water T=0 - 20°C; 18 h;
参考文献
DENDREON CORPORATION
Patent: WO2004/58688 A1, 2004 ;
Location in patent: Page 48 ;
WO 2004/058688 A1
反应条件
1: With trimethylsilyl iodide in acetonitrile T=0°C; 0.5 h; Inert atmosphere; 2: With methanol in acetonitrile T=20°C; 0.166667 h; Inert atmospheresolid phase reaction;
参考文献
Souto, Jose A.; Vaz, Esther; Lepore, Ilaria; Poeppler, Ann-Christin; Franci, Gianluigi; Alvarez, Rosana; Altucci, Lucia; De Lera, Angel R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 12 p. 4654 - 4667
反应条件
1: 39 percent / NBS / CCl4 / 80 °C 2: NaN3 / dimethylformamide / 20 h / 20 °C 3: 80 percent / Ph3P / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme
参考文献
Reiner, John E.; Siev, Daniel V.; Araldi, Gian-Luca; Cui, Jingrong Jean; Ho, Jonathan Z.; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H.; Lee, Kuen-Shan S.; Minami, Nathaniel K.; Gibson, Tony S.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 8 p. 1203 - 1208
反应条件
1: 56 percent / SOCl2; NMM / dimethylformamide / 5 h / 0 - 20 °C 2: 39 percent / NBS / CCl4 / 80 °C 3: NaN3 / dimethylformamide / 20 h / 20 °C 4: 80 percent / Ph3P / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme
参考文献
Reiner, John E.; Siev, Daniel V.; Araldi, Gian-Luca; Cui, Jingrong Jean; Ho, Jonathan Z.; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H.; Lee, Kuen-Shan S.; Minami, Nathaniel K.; Gibson, Tony S.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 8 p. 1203 - 1208
反应条件
1: 89 percent / aq. NH3 / methanol / 16 h / 20 °C 2: 56 percent / SOCl2; NMM / dimethylformamide / 5 h / 0 - 20 °C 3: 39 percent / NBS / CCl4 / 80 °C 4: NaN3 / dimethylformamide / 20 h / 20 °C 5: 80 percent / Ph3P / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme
参考文献
Reiner, John E.; Siev, Daniel V.; Araldi, Gian-Luca; Cui, Jingrong Jean; Ho, Jonathan Z.; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H.; Lee, Kuen-Shan S.; Minami, Nathaniel K.; Gibson, Tony S.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 8 p. 1203 - 1208
反应条件
1: NaN3 / dimethylformamide / 20 h / 20 °C 2: 80 percent / Ph3P / tetrahydrofuran; H2O / 20 h / 20 °C View Scheme
参考文献
Reiner, John E.; Siev, Daniel V.; Araldi, Gian-Luca; Cui, Jingrong Jean; Ho, Jonathan Z.; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H.; Lee, Kuen-Shan S.; Minami, Nathaniel K.; Gibson, Tony S.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 8 p. 1203 - 1208
