6-甲基-4-硝基-2-氰基吡啶合成路线 （共 7 条）
反应条件
1: 2-methyl-4-nitropyridine 1-oxide With dimethyl sulfate T=70°C; 1 h; 2: potassium cyanide in water T=0 - 20°C; Reissert-Kaufmann reaction;
参考文献
Guery, Sebastien; Rival, Yveline; Wermuth, Camille G.
Synthetic Communications, 2002 , vol. 32, # 11 p. 1715 - 1719
反应条件
dimethyl sulfate in hexane; water; ethyl acetate
参考文献
Kureha Kagaku Kogyo K.K.
Patent: US6610853 B1, 2003 ;
反应条件
in water T=-8°C; 0.25 h;
参考文献
US2007/197553 A1, ;
Page/Page column 17 ;
US 20070197553 A1
反应条件
1: 98 percent / conc. sulfuric acid, conc.nitric acid / 2 h / 160 °C 2: 1.) dimethyl sulfate / 1.) 65-70 deg C, 2 h, 2.) water, overnights View Scheme
参考文献
Journal of the Chemical Society - Dalton Transactions, , # 11 p. 2197 - 2205
反应条件
1: With sulfuric acid in water T=120°C; 2 h; 2: With sodium nitrite in water T=12 - 80°C; 2 h;
参考文献
Jaeschke, Georg; Spooren, Will; Vieira, Eric
Patent: US2007/197553 A1, 2007 ;
Location in patent: Page/Page column 17 ;
US 20070197553 A1
反应条件
1.1: 90 percent sulfuric acid / H2O / 2 h / 120 °C 1.2: 91 percent / sodium nitrite / H2O / 2 h / 20 - 80 °C 2.1: 80 percent / 37 percent hydrochloric acid / 2 h / 100 °C View Scheme
参考文献
Guery, Sebastien; Rival, Yveline; Wermuth, Camille G.
Synthetic Communications, 2002 , vol. 32, # 11 p. 1715 - 1719
反应条件
indium; ammonium chloride in ethanol; water
T=60°C; 72 h;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2005/30213 A1, 2005 ;
Location in patent: Page/Page column 168 ;
WO 2005/030213 A1
