6-甲基-4-硝基吡啶-2-羧酸合成路线 （共 5 条）
反应条件
1: With sulfuric acid in water T=120°C; 2 h; 2: With sodium nitrite in water T=12 - 80°C; 2 h;
参考文献
Jaeschke, Georg; Spooren, Will; Vieira, Eric
Patent: US2007/197553 A1, 2007 ;
Location in patent: Page/Page column 17 ;
US 20070197553 A1
反应条件
1.1: dimethyl sulfate / 1 h / 70 °C 1.2: 50 percent / H2O / 0 - 20 °C 2.1: 90 percent sulfuric acid / H2O / 2 h / 120 °C 2.2: 91 percent / sodium nitrite / H2O / 2 h / 20 - 80 °C View Scheme
参考文献
Hoare, Jason L.; Cavell, Kingsley J.; Hecker, Richard; Skelton, Brian W.; White, Allan H.
Journal of the Chemical Society - Dalton Transactions, 1996 , # 11 p. 2197 - 2205
反应条件
1: 98 percent / conc. sulfuric acid, conc.nitric acid / 2 h / 160 °C 2: 1.) dimethyl sulfate / 1.) 65-70 deg C, 2 h, 2.) water, overnights 3: 1.) 90percent sulfuric acid 2.) aq. sodium nitrite / 1.) 120 deg C, 2 h, 2.) 20-25 deg C, 1 h, 80 deg C, 1 h View Scheme
参考文献
Hoare, Jason L.; Cavell, Kingsley J.; Hecker, Richard; Skelton, Brian W.; White, Allan H.
Journal of the Chemical Society - Dalton Transactions, 1996 , # 11 p. 2197 - 2205
反应条件
hydrogenchloride T=100°C; 2 h;
参考文献
Guery, Sebastien; Rival, Yveline; Wermuth, Camille G.
Synthetic Communications, 2002 , vol. 32, # 11 p. 1715 - 1719
反应条件
hydrogen bromide in water
T=100°C;
参考文献
Jaeschke, Georg; Spooren, Will; Vieira, Eric
Patent: US2007/197553 A1, 2007 ;
Location in patent: Page/Page column 17; 18 ;
US 20070197553 A1
