7-氨基-3-{[(5-甲基-1,3,4-噻二唑-2-基)硫]甲基}头孢霉素烷酸合成路线 （共 11 条）
反应条件
pyridine; methanol 1.) CH2Cl2, 2.) from 0 to 5 deg C, 15 min; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 53, # 5 p. 983 - 991
反应条件
pyridine; hydrogenchloride; nitrogen in methanol; dichloromethane; 1-chloro-1,1-difluoro-methane; water
参考文献
Bristol-Myers Company
Patent: US4868294 A1, 1989 ;
反应条件
boron trifluoride in acetonitrile T=30°C; 1.5 h;
参考文献
Saikawa; Takano; Momonoi; et al.
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 12 p. 5534 - 5538
反应条件
1: iodotrimethylsilane / CH2Cl2 / 1 h 2: 1.) pyridine, 2.) MeOH / 1.) CH2Cl2, 2.) from 0 to 5 deg C, 15 min View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 5 p. 983 - 991
反应条件
1: iodotrimethylsilane (TMSI) / 1,1,2-trichloro-1,2,2-trifluoro-ethane / 2 h / 25 - 30 °C 2: 1.) pyridine, 2.) MeOH / 1.) freon TF, CH2Cl2, from 0 to 5 deg C, 30 min, 2.) from 0 to 5 deg, 10 min View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 5 p. 983 - 991
反应条件
pyridine; methanol 1.) freon TF, CH2Cl2, from 0 to 5 deg C, 30 min, 2.) from 0 to 5 deg, 10 min; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 53, # 5 p. 983 - 991
反应条件
hydrogenchloride; ammonium hydroxide; carbon 1. ) water, 20 deg C; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 41, # 22 p. 5133 - 5139
反应条件
(i) SOCl2, DMF, (ii) /BRN= 629621/, Et3N, CH2Cl2; Multistep reaction;
参考文献
Gericke; Rogalski
Arzneimittel-Forschung/Drug Research, 1979 , vol. 29, # 2 A p. 362 - 369
反应条件
phosphate buffer; PGA Coli A T=4°C; pH 7.5;
参考文献
Journal of Organic Chemistry, , vol. 62, # 26 p. 9099 - 9106
反应条件
phosphate buffer; folic Acid T=4°C; Rate constant;
参考文献
Journal of Organic Chemistry, , vol. 62, # 26 p. 9099 - 9106
