3-硝基-1,8-萘二甲酸酐合成路线 （共 27 条）
反应条件
sodium nitrate; sulfuric acid T=0°C; 1 h;
参考文献
Li, Zhigang; Yang, Qing; Qian, Xuhong
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 7 p. 1769 - 1772
反应条件
in ethanol 0.5 h; Heating;
参考文献
Van Quaquebeke, Eric; Mahieu, Tine; Dumont, Patrick; Dewelle, Janique; Ribaucour, Fabrice; Simon, Gentiane; Sauvage, Sebastien; Gaussin, Jean-Francois; Tuti, Jerome; El Yazidi, Mohamed; Van Vynckt, Frank; Mijatovic, Tatjana; Lefranc, Florence; Darro, Francis; Kiss, Robert
Journal of Medicinal Chemistry, 2007 , vol. 50, # 17 p. 4122 - 4134
反应条件
1: With sodium hydroxide; water 2: With water; acetic acid; mercury(II) oxide 96 h; Reflux;
参考文献
Lee, Jung-Jae; Noll, Bruce C.; Smith, Bradley D.
Organic Letters, 2008 , vol. 10, # 9 p. 1735 - 1738
反应条件
sodium hydroxide; mercury(II) oxide in water; acetic acid 98 h; Heating;
参考文献
Nakayama; Okutome; Matsui; Kurumi; Sakurai; Aoyama; Fujii
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3968 - 3980
反应条件
sodium hydroxide; sulfuric acid; mercury(II) oxide 1.) water, acetic acid, reflux, 98 h; 2.) reflux; Multistep reaction;
参考文献
Nakayama; Okutome; Matsui; Kurumi; Sakurai; Aoyama; Fujii
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3968 - 3980
反应条件
hydrogen; palladium on activated charcoal in N,N-dimethyl-formamide P=2206.5 Torr; 4 h; Ambient temperature;
参考文献
Middleton; Parrick; Clarke; Wardman
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 849 - 855
反应条件
in hydrogenchloride; acetic acid
参考文献
Warner-Lambert Company
Patent: US6177423 B1, 2001 ;
反应条件
1: 93 percent / ethanol / 0.5 h / Heating 2: 91 percent / formic acid; triethylamine / Pd/C / ethanol / 0.67 h / Heating View Scheme
参考文献
Li, Shasha; Zhong, Wenhe; Li, Zhongjun; Meng, Xiangbao
European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 546 - 552
反应条件
1.1: aq. NaOH; HgO; glacial AcOH / 72 h / Heating 1.2: aq. HCl / 4 h / Heating 2.1: 90 percent / 10percent aq. NaOH; H2 / 10percent Pd/C / 4 h / 20 °C / 2585.81 Torr 3.1: 74 percent / aq. H2SO4; NaNO2 / 10 °C 4.1: p-diazoniumbenzenesulfonate; aq. NaHCO3 / 60 °C 4.2: 15 percent / NaHSO3 / 0.5 h / 50 °C View Scheme
参考文献
Duffy; Darcy; Delorme; Dillon; Eppley; Erickson-Miller; Giampa; Hopson; Huang; Keenan; Lamb; Leong; Liu; Miller; Price; Rosen; Shah; Shaw; Smith; Stark; Tian; Tyree; Wiggall; Zhang; Luengo
Journal of Medicinal Chemistry, 2001 , vol. 44, # 22 p. 3730 - 3745
反应条件
1: 1.) NaOH, yellow mercuric oxide, glacial acetic acid, 2.) 5 M HCl / 1.) H2O, reflux 4 d, 2.) reflux, 3 h 2: 90 percent / 1,2-dimethoxy-ethane; diethyl ether View Scheme
参考文献
Kice, John L.; Lotey, Harvinder
Journal of Organic Chemistry, 1989 , vol. 54, # 15 p. 3596 - 3602
