3-硝基-1,8-萘二甲酸酐合成路线 （共 27 条）
反应条件
hydrogenchloride; sodium hydroxide; thionyl chloride; mercury(II) diacetate Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Moseley, Jonathan D.; Gilday, John P.
Tetrahedron, 2006 , vol. 62, # 19 p. 4690 - 4697
反应条件
1.1: aq. NaOH; HgO; glacial AcOH / 72 h / Heating
1.2: aq. HCl / 4 h / Heating
2.1: 90 percent / 10percent aq. NaOH; H2 / 10percent Pd/C / 4 h / 20 °C / 2585.81 Torr
3.1: 74 percent / aq. H2SO4; NaNO2 / 10 °C
View Scheme
参考文献
Duffy; Darcy; Delorme; Dillon; Eppley; Erickson-Miller; Giampa; Hopson; Huang; Keenan; Lamb; Leong; Liu; Miller; Price; Rosen; Shah; Shaw; Smith; Stark; Tian; Tyree; Wiggall; Zhang; Luengo
Journal of Medicinal Chemistry, 2001 , vol. 44, # 22 p. 3730 - 3745
反应条件
1: 79 percent / Et3N / toluene / 6 h / Heating
2: 74 percent / H2 / 5percent Pd/C / ethyl acetate / 3 h / 2068.6 Torr
3: 1.) aq. HCl, NaNO2, 2.) NaN3 / 1.) from 0 deg C to 5 deg C, 1 h
4: 47 percent / 10percent aq. NaOH / methanol / 0.25 h / Ambient temperature
View Scheme
参考文献
Ares; Kador; Miller
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2384 - 2389
反应条件
ammonium hydroxide in N,N-dimethyl-formamide
T=200°C; 12 h;
参考文献
David-Cordonnier, Marie-Helene; Hildebrand, Marie-Paule; Baldeyrou, Brigitte; Lansiaux, Amelie; Keuser, Christoph; Benzschawel, Kerstin; Lemster, Thomas; Pindur, Ulf
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 6 p. 752 - 771
反应条件
in ethanol
2 h; Ambient temperature;
参考文献
Fernandez Brana; Martinez Sanz; Castellano; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 3 p. 207 - 212
反应条件
1: 68.2 percent / ethanol / 3 h / Ambient temperature
2: 79.5 percent / H2 / Pd/C 10percent / ethanol
View Scheme
参考文献
Fernandez Brana; Martinez Sanz; Castellano; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 3 p. 207 - 212
反应条件
1: hydrogen / 10 percent Pd/C / dimethylformamide / 2280 Torr
2: 79 percent / ethanol / 2 h / Ambient temperature
View Scheme
参考文献
Fernandez Brana; Martinez Sanz; Castellano; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 3 p. 207 - 212
反应条件
1: 93 percent / ethanol / 0.5 h / Heating
2: 91 percent / formic acid; triethylamine / Pd/C / ethanol / 0.67 h / Heating
3: 98 percent / pyridine / 5 h / 20 °C
View Scheme
参考文献
Van Quaquebeke, Eric; Mahieu, Tine; Dumont, Patrick; Dewelle, Janique; Ribaucour, Fabrice; Simon, Gentiane; Sauvage, Sebastien; Gaussin, Jean-Francois; Tuti, Jerome; El Yazidi, Mohamed; Van Vynckt, Frank; Mijatovic, Tatjana; Lefranc, Florence; Darro, Francis; Kiss, Robert
Journal of Medicinal Chemistry, 2007 , vol. 50, # 17 p. 4122 - 4134
反应条件
in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Fernandez Brana; Martinez Sanz; Castellano; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 3 p. 207 - 212
反应条件
in ethanol
1 h; Reflux;
参考文献
Sk, Ugir Hossain; Prakasha Gowda; Crampsie, Melissa A.; Yun, Jong K.; Spratt, Thomas E.; Amin, Shantu; Sharma, Arun K.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 8 p. 3331 - 3338
