3-硝基-1,8-萘二甲酸酐合成路线 （共 27 条）
反应条件
1.1: 1,4-dioxane / 2.5 h / |Reflux
2.1: palladium on activated charcoal; hydrogen / tetrahydrofuran; ethanol
3.1: sodium nitrite; hydrogenchloride / water / 1 h / -5 - 0 °C
3.2: 1 h / |Cooling
4.1: iron sulphate heptahydrate; tert.-butylhydroperoxide / water / 0.33 h / 20 °C
View Scheme
参考文献
Ma, Zhao; Sun, Wei; Chen, Laizhong; Li, Jing; Liu, Zhenzhen; Bai, Haixiu; Zhu, Mengyuan; Du, Lupei; Shi, Xiaodong; Li, Minyong
Chemical Communications, 2013 , vol. 49, # 57 p. 6295 - 6297
反应条件
1: aq. NaOH; HgO
2: 22 percent / SOCl2
View Scheme
参考文献
Nakayama; Okutome; Matsui; Kurumi; Sakurai; Aoyama; Fujii
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3968 - 3980
反应条件
sodium hydroxide; phosphorus pentachloride; mercury(II) oxide
1.) water, acetic acid, reflux, 98 h; 2.) EtOAc, r.t.; Multistep reaction. Title compound not separated from byproducts;
参考文献
Nakayama; Okutome; Matsui; Kurumi; Sakurai; Aoyama; Fujii
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3968 - 3980
参考文献
Peduto, Antonella; Pagano, Bruno; Petronzi, Carmen; Massa, Antonio; Esposito, Veronica; Virgilio, Antonella; Paduano, Francesco; Trapasso, Francesco; Fiorito, Filomena; Florio, Salvatore; Giancola, Concetta; Galeone, Aldo; Filosa, Rosanna
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6419 - 6429
反应条件
in toluene
2 h; Heating;
参考文献
Zee-Cheng; Cheng
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1216 - 1222
反应条件
in toluene
2 h; Heating;
参考文献
Zee-Cheng; Cheng
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1216 - 1222
反应条件
in ethanol
3 h; Ambient temperature;
参考文献
da Settimo; Primofiore; Livi; Tonetti; Tellini; Bianchini
Farmaco, Edizione Scientifica, 1982 , vol. 37, # 2 p. 105 - 115
