2,4-二氯-6-甲基苯胺合成路线 （共 11 条）
反应条件
hydrogenchloride in ethanol 18 h; Heating;
参考文献
Guengoer, Timur; Fouquet, Andre; Teulon, Jean-Marie; Provost, Daniel; Cazes, Michele; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4455 - 4463
反应条件
1: Cl2 / acetic acid; CHCl3 2: 80 percent / conc. aq. HCl / aq. ethanol / 18 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4455 - 4463
反应条件
1: acetic acid; chlorine 2: aqueous hydrochloric acid View Scheme
参考文献
Journal of the Chemical Society, , p. 691,694
反应条件
hydrogenchloride; tin
参考文献
Journal of the Chemical Society, , vol. 81, p. 1335
Journal of the Chemical Society, , vol. 89, p. 1454
参考文献
Wynne; Greeves
Chem. News J. Ind. Sci., 1895 , vol. 72, p. 58
Chem. Zentralbl., 1895 , vol. 66, # II p. 530
反应条件
durch Austausch von NH2 gegen CN;
参考文献
Claus; Stapelberg
Justus Liebigs Annalen der Chemie, 1893 , vol. 274, p. 291
反应条件
(i) (diazotization), (ii) (heating), (iii) NBS; Multistep reaction;
参考文献
Bunnett,J.F.; Sridharan,S.
Journal of Organic Chemistry, 1979 , vol. 44, # 9 p. 1458 - 1463
反应条件
1: durch Austausch von NH2 gegen CN
2: alcoholic KOH-solution
View Scheme
参考文献
Claus; Stapelberg
Justus Liebigs Annalen der Chemie, 1893 , vol. 274, p. 291
反应条件
1: (i) (diazotization), (ii) (heating), (iii) NBS
2: (i) Mg, (ii) /BRN= 635680/
3: SOCl2
4: NaHCO3 / methanol
View Scheme
参考文献
Bunnett,J.F.; Sridharan,S.
Journal of Organic Chemistry, 1979 , vol. 44, # 9 p. 1458 - 1463
反应条件
1: hydrogenchloride; sodium nitrite; sodium tetrafluoroborate / water / 0.75 h / 0 °C
2: potassium acetate; 18-crown-6 ether / chloroform / 1.5 h / 20 - 25 °C
View Scheme
参考文献
AVENTIS AGRICULTURE; MERIAL LIMITED; Soll, Mark David; Le Hir de Fallois, Loic Patrick; Huber, Scot Kevin; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Jacobs, Robert Toms
Patent: US2014/80862 A1, 2014 ;
